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SGD:APN2

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) APN2 ( synonyms: YBL019W, DNA-(apurinic or apyrimidinic site) lyase APN2, ETH1 )
Protein Name(s) Class II abasic (AP) endonuclease involved in repair of DNA damage,
External Links
SGD S000000115

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR020848

F

From SGD

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

SGD_REF:S000041997
PMID:10806210[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

SGD_REF:S000124037

IEA: Inferred from Electronic Annotation

EC:4.2.99.18

F

From SGD

GO:0004518

nuclease activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004808

F

From SGD

GO:0004519

endonuclease activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR020848

F

From SGD

GO:0005622

intracellular

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR020848

C

From SGD

GO:0005634

nucleus

SGD_REF:S000041997
PMID:10806210[1]

IC: Inferred by Curator

GO:0003906

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0006281

DNA repair

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR020848
InterPro:IPR004808

P

From SGD

GO:0006281

DNA repair

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

From SGD

GO:0006284

base-excision repair

SGD_REF:S000050984
PMID:9765213[2]

IGI: Inferred from Genetic Interaction

SGD:S000001597

P

From SGD

GO:0006974

response to DNA damage stimulus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

From SGD

GO:0008081

phosphoric diester hydrolase activity

SGD_REF:S000059907
PMID:11238902[3]

IDA: Inferred from Direct Assay

F

From SGD

GO:0008270

zinc ion binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR010666

F

From SGD

GO:0008311

double-stranded DNA specific 3'-5' exodeoxyribonuclease activity

SGD_REF:S000059907
PMID:11238902[3]

IDA: Inferred from Direct Assay

F

From SGD

GO:0016829

lyase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0456

F

From SGD

GO:0090305

nucleic acid phosphodiester bond hydrolysis

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004808

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Unk, I et al. (2000) Apurinic endonuclease activity of yeast Apn2 protein. J. Biol. Chem. 275 22427-34 PubMed GONUTS page
  2. Johnson, RE et al. (1998) Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 12 3137-43 PubMed GONUTS page
  3. 3.0 3.1 Unk, I et al. (2001) 3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage. Mol. Cell. Biol. 21 1656-61 PubMed GONUTS page
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