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SGD:AFG3

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) AFG3 ( synonyms: YER017C, YTA10 )
Protein Name(s) Component of the mitochondrial inner membrane m-AAA protease,
External Links
SGD S000000819

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0004222

metalloendopeptidase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000642
InterPro:IPR005936
InterPro:IPR011546

F

From SGD

GO:0005515

protein binding

SGD_REF:S000134962
PMID:19748354[1]

IPI: Inferred from Physical Interaction

SGD:S000004695

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546
InterPro:IPR003960
InterPro:IPR000642
InterPro:IPR003959

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

From SGD

GO:0005743

mitochondrial inner membrane

SGD_REF:S000050177
PMID:7926051[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005745

m-AAA complex

SGD_REF:S000055187
PMID:8681382[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006461

protein complex assembly

SGD_REF:S000055187
PMID:8681382[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006465

signal peptide processing

SGD_REF:S000071826
PMID:12417197[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000055187
PMID:8681382[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000642

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

From SGD

GO:0008233

peptidase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

From SGD

GO:0008237

metallopeptidase activity

SGD_REF:S000055187
PMID:8681382[4]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0008237

metallopeptidase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0482

F

From SGD

GO:0008270

zinc ion binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

F

From SGD

GO:0016020

membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

C

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From SGD

GO:0016787

hydrolase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From SGD

GO:0016887

ATPase activity

SGD_REF:S000053170
PMID:7900428[6]

ISS: Inferred from Sequence or Structural Similarity

F

From SGD

GO:0016887

ATPase activity

SGD_REF:S000134962
PMID:19748354[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0016887

ATPase activity

SGD_REF:S000134962
PMID:19748354[1]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0017111

nucleoside-triphosphatase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0030163

protein catabolic process

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

P

From SGD

GO:0031966

mitochondrial membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0171

C

From SGD

GO:0045041

protein import into mitochondrial intermembrane space

SGD_REF:S000071826
PMID:12417197[5]

TAS: Traceable Author Statement

P

From SGD

GO:0046872

metal ion binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From SGD

GO:0097002

mitochondrial inner boundary membrane

SGD_REF:S000128411
PMID:19019989[7]

IDA: Inferred from Direct Assay

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Augustin, S et al. (2009) An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol. Cell 35 574-85 PubMed GONUTS page
  2. Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. Tauer, R et al. (1994) Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial function. FEBS Lett. 353 197-200 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Arlt, H et al. (1996) The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 85 875-85 PubMed GONUTS page
  5. 5.0 5.1 Esser, K et al. (2002) A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J. Mol. Biol. 323 835-43 PubMed GONUTS page
  6. Guelin, E et al. (1994) Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA-protein family. Yeast 10 1389-94 PubMed GONUTS page
  7. Suppanz, IE et al. (2009) The m-AAA protease processes cytochrome c peroxidase preferentially at the inner boundary membrane of mitochondria. Mol. Biol. Cell 20 572-80 PubMed GONUTS page
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