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SGD:ACS1

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ACS1 ( synonyms: YAL054C, FUN44, acetate--CoA ligase 1 )
Protein Name(s) Acetyl-coA synthetase isoform,
External Links
SGD S000000050

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0003824

catalytic activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000047927
PMID:8910545[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011904

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000124037

IEA: Inferred from Electronic Annotation

EC:6.2.1.1

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000075100
PMID:14576278[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0173

C

From SGD

GO:0005783

endoplasmic reticulum

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

From SGD

GO:0005829

cytosol

SGD_REF:S000048464
PMID:9711835[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006085

acetyl-CoA biosynthetic process

SGD_REF:S000047927
PMID:8910545[1]

IDA: Inferred from Direct Assay

P

From SGD

GO:0008152

metabolic process

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

P

From SGD

GO:0016021

integral to membrane

SGD_REF:S000114049
PMID:12192589[5]

ISM: Inferred from Sequence Model

C

From SGD

GO:0016208

AMP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011904

F

From SGD

GO:0016573

histone acetylation

SGD_REF:S000117290
PMID:16857587[6]

IGI: Inferred from Genetic Interaction

SGD:S000004143

P

From SGD

GO:0016874

ligase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0436

F

From SGD

GO:0016880

acid-ammonia (or amide) ligase activity

SGD_REF:S000136074
PMID:18305111[7]

IDA: Inferred from Direct Assay

F

From SGD

GO:0019654

acetate fermentation

SGD_REF:S000047705
PMID:1363452[8]

IMP: Inferred from Mutant Phenotype

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 van den Berg, MA et al. (1996) The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J. Biol. Chem. 271 28953-9 PubMed GONUTS page
  2. Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  3. Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  4. de Jong-Gubbels, P et al. (1998) Overproduction of acetyl-coenzyme A synthetase isoenzymes in respiring Saccharomyces cerevisiae cells does not reduce acetate production after exposure to glucose excess. FEMS Microbiol. Lett. 165 15-20 PubMed GONUTS page
  5. De Hertogh, B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct. Integr. Genomics 2 154-70 PubMed GONUTS page
  6. Takahashi, H et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol. Cell 23 207-17 PubMed GONUTS page
  7. Abe, T et al. (2008) Discovery of amide (peptide) bond synthetic activity in Acyl-CoA synthetase. J. Biol. Chem. 283 11312-21 PubMed GONUTS page
  8. De Virgilio, C et al. (1992) Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8 1043-51 PubMed GONUTS page
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