RAT:TRDN

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Trdn (ECO:0000312 with RGD:619856)
Protein Name(s)	Triadin
External Links
UniProt	Q9QX75
EMBL	AJ243303 AJ243304 AJ812275 AJ812276 AF220558 AF220559 AABR06001232 AABR06001233 AABR06001234 AABR06001235 AABR06001236 AABR06001237 AABR06001238 AABR06001239 AABR06001240 AABR06001241 AABR06001242 AABR06001243 CH474002
RefSeq	NP_067698.1
UniGene	Rn.228699 Rn.41863
STRING	10116.ENSRNOP00000017427
PaxDb	Q5DVI6
PRIDE	Q9QX75
Ensembl	ENSRNOT00000017428
GeneID	59299
KEGG	rno:59299
CTD	10345
RGD	619856
eggNOG	NOG85242
GeneTree	ENSGT00510000049207
HOGENOM	HOG000172367
HOVERGEN	HBG014932
TreeFam	TF350396
Reactome	REACT_198302
NextBio	35575116
PRO	PR:Q9JKZ6
Proteomes	UP000002494
Genevestigator	Q9QX75
GO	GO:0005783 GO:0016021 GO:0043231 GO:0030314 GO:0014701 GO:0042383 GO:0016529 GO:0006874 GO:0031122 GO:0090158 GO:0014902 GO:0051280 GO:0051281 GO:0010880 GO:0014070
InterPro	IPR007943 IPR010798
PANTHER	PTHR14106
Pfam	PF05279

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005886	plasma membrane	PMID:22422768^[1]	ECO:0000314			C		Figure 2A.	complete CACAO 4809
part_of	GO:0005886	plasma membrane	PMID:22422768^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014701	junctional sarcoplasmic reticulum membrane	PMID:22505613^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:22422768^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:E9Q9K5	C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0030314	junctional membrane complex	PMID:22505613^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22422768^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090158	endoplasmic reticulum membrane organization	PMID:22505613^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PMID:21811790^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	PMID:16176928^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:10713145^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:22505613^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030314	junctional membrane complex	PMID:22505613^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:21811790^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014902	myotube differentiation	PMID:10713145^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014701	junctional sarcoplasmic reticulum membrane	PMID:7565919^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18602130^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:17569730^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:18845610^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:10713145^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:22505613^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 UniProtKB:P82179	P		Seeded From UniProt	complete
involved_in	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 UniProtKB:P82179	P		Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924007 PANTHER:PTN001019999 UniProtKB:Q13061	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 UniProtKB:P82179	F		Seeded From UniProt	complete
part_of	GO:0014701	junctional sarcoplasmic reticulum membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 RGD:619856	C		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 RGD:619856 UniProtKB:P82179	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001019999 RGD:619856 UniProtKB:Q13061	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010798	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007943	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010798	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010798	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492 UniProtKB-SubCell:SL-0166	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Roux-Buisson, N et al. (2012) Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum. Mol. Genet. 21 2759-67 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Fourest-Lieuvin, A et al. (2012) Role of triadin in the organization of reticulum membrane at the muscle triad. J. Cell. Sci. 125 3443-53 PubMed GONUTS page
↑ ^3.0 ^3.1 Oláh, T et al. (2011) Trisk 32 regulates IP(3) receptors in rat skeletal myoblasts. Pflugers Arch. 462 599-610 PubMed GONUTS page
↑ Rezgui, SS et al. (2005) Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes. J. Biol. Chem. 280 39302-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Marty, I et al. (2000) Cloning and characterization of a new isoform of skeletal muscle triadin. J. Biol. Chem. 275 8206-12 PubMed GONUTS page
↑ Carl, SL et al. (1995) Immunolocalization of triadin, DHP receptors, and ryanodine receptors in adult and developing skeletal muscle of rats. Muscle Nerve 18 1232-43 PubMed GONUTS page
↑ Royland, JE & Kodavanti, PR (2008) Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action. Toxicol. Appl. Pharmacol. 231 179-96 PubMed GONUTS page
↑ Terentyev, D et al. (2007) Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J. Physiol. (Lond.) 583 71-80 PubMed GONUTS page
↑ Fodor, J et al. (2008) Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture. J. Physiol. (Lond.) 586 5803-18 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22422768-1] 1.0 ^1.1 ^1.2 ^1.3 Roux-Buisson, N et al. (2012) Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum. Mol. Genet. 21 2759-67 PubMed GONUTS page

[PMID:22505613-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Fourest-Lieuvin, A et al. (2012) Role of triadin in the organization of reticulum membrane at the muscle triad. J. Cell. Sci. 125 3443-53 PubMed GONUTS page

[PMID:21811790-3] 3.0 ^3.1 Oláh, T et al. (2011) Trisk 32 regulates IP(3) receptors in rat skeletal myoblasts. Pflugers Arch. 462 599-610 PubMed GONUTS page

[PMID:16176928-4] Rezgui, SS et al. (2005) Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes. J. Biol. Chem. 280 39302-8 PubMed GONUTS page

[PMID:10713145-5] 5.0 ^5.1 ^5.2 Marty, I et al. (2000) Cloning and characterization of a new isoform of skeletal muscle triadin. J. Biol. Chem. 275 8206-12 PubMed GONUTS page

[PMID:7565919-6] Carl, SL et al. (1995) Immunolocalization of triadin, DHP receptors, and ryanodine receptors in adult and developing skeletal muscle of rats. Muscle Nerve 18 1232-43 PubMed GONUTS page

[PMID:18602130-7] Royland, JE & Kodavanti, PR (2008) Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action. Toxicol. Appl. Pharmacol. 231 179-96 PubMed GONUTS page

[PMID:17569730-8] Terentyev, D et al. (2007) Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J. Physiol. (Lond.) 583 71-80 PubMed GONUTS page

[PMID:18845610-9] Fodor, J et al. (2008) Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture. J. Physiol. (Lond.) 586 5803-18 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:TRDN

Contents

Annotations

Notes

References

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