RAT:SYUA

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Snca
Protein Name(s)	Alpha-synuclein
External Links
UniProt	P37377
EMBL	S73007 S73008 S73009 AF007758 AY550005 AY550006 BC087682
PIR	B43959
RefSeq	NP_062042.1 XP_006236653.1 XP_017447989.1
UniGene	Rn.1827
ProteinModelPortal	P37377
SMR	P37377
BioGrid	247897
IntAct	P37377
iPTMnet	P37377
PhosphoSitePlus	P37377
World-2DPAGE	0004:P37377
PeptideAtlas	P37377
PRIDE	P37377
Ensembl	ENSRNOT00000039247
GeneID	29219
KEGG	rno:29219
UCSC	RGD:3729
CTD	6622
RGD	3729
GeneTree	ENSGT00390000016161
HOGENOM	HOG000008691
HOVERGEN	HBG000481
InParanoid	P37377
KO	K04528
OMA	MPPEEEY
OrthoDB	EOG091G11PA
PhylomeDB	P37377
TreeFam	TF332776
PRO	PR:P37377
Proteomes	UP000002494
Bgee	ENSRNOG00000008656
Genevisible	P37377
GO	GO:0015629 GO:0043679 GO:0005938 GO:0030054 GO:0005737 GO:0030659 GO:0005829 GO:0005615 GO:0005794 GO:0030426 GO:0016234 GO:0043231 GO:0005739 GO:0043025 GO:0005640 GO:0048471 GO:0005886 GO:0031092 GO:0098794 GO:0005840 GO:0005791 GO:0099512 GO:0008021 GO:0043195 GO:0050544 GO:0048487 GO:0005509 GO:0005507 GO:0043027 GO:0019899 GO:0008198 GO:0042802 GO:0000287 GO:0008017 GO:0016491 GO:0043274 GO:0005543 GO:0019904 GO:0047485 GO:0008270 GO:0006919 GO:0008344 GO:0007568 GO:0048148 GO:0071280 GO:0044344 GO:0034599 GO:0042416 GO:0060079 GO:0006631 GO:0060291 GO:0001774 GO:0042775 GO:0007006 GO:1904715 GO:0045963 GO:0051585 GO:0045920 GO:0035067 GO:0031115 GO:0032769 GO:0043524 GO:0051622 GO:0010642 GO:0001933 GO:0051612 GO:0070495 GO:0032410 GO:0006638 GO:0006644 GO:0045807 GO:1903284 GO:1903285 GO:0060732 GO:0001956 GO:0033138 GO:0071902 GO:0001921 GO:0051281 GO:0031648 GO:0031623 GO:0050812 GO:0014059 GO:0014048 GO:0040012 GO:0048169 GO:0043030 GO:1901214 GO:0010517 GO:1905606 GO:0042220 GO:0042493 GO:0034341 GO:0070555 GO:0010040 GO:0032496 GO:0032026 GO:0050808 GO:0001963 GO:0048488
InterPro	IPR001058 IPR002460
PANTHER	PTHR13820 PTHR13820:SF12
Pfam	PF01387
PRINTS	PR01212 PR01211

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001170	negative regulation of ATP biosynthetic process	PMID:28337542^[1]	ECO:0000314			P		Expression of alpha-synuclein, as seen in Figure 7, shows reduced mitochondrial ATP production in rat cortical neurons. Alpha-synuclein Rat	complete CACAO 12791
	GO:0032865	ERMES complex	PMID:28337542^[1]	ECO:0000314			C		Alpha-Synuclein is a MAM protein (Mitochondria associated ER membranes) and can be seen as such in Figure 8A. Alpha-synuclein Rat	complete CACAO 12792
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:24876496^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	PMID:24403142^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5S007	P		Seeded From UniProt	complete
involved_in	GO:0045963	negative regulation of dopamine metabolic process	PMID:11943812^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:11943812^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11943812^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:11943812^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:11698390^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
involved_in	GO:1904307	response to desipramine	PMID:19818834^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:16837598^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:12000718^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:18800064^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:18001274^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:12917442^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	PMID:12562524^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	PMID:12127102^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:17635667^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	PMID:11821392^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70829	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:11679584^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:15804428^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:10777786^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:17275196^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:14622225^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:12821390^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12917442^[11]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1307807	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:11821392^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70829	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16981894^[22]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2494	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11943812^[4]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3853	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:18001274^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:15795473^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11810180^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	PMID:11810180^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17635667^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11679584^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11810180^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	PMID:11810180^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	PMID:19429081^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:19429081^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:19429081^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:19429081^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12917442^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11032911^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	PMID:11810180^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19118601^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:11679584^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0043027	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0050812	regulation of acyl-CoA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	F		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0043030	regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	F		Seeded From UniProt	complete
involved_in	GO:0042775	mitochondrial ATP synthesis coupled electron transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0042416	dopamine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	F		Seeded From UniProt	complete
involved_in	GO:0040012	regulation of locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0014048	regulation of glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0007006	mitochondrial membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0006638	neutral lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	C		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0001956	positive regulation of neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55042 ensembl:ENSMUSP00000109907	P		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1904715	negative regulation of chaperone-mediated autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1903285	positive regulation of hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1903284	positive regulation of glutathione peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0099512	supramolecular fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0060732	positive regulation of inositol phosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051622	negative regulation of norepinephrine uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051621	regulation of norepinephrine uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0034341	response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032769	negative regulation of monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032410	negative regulation of transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032026	response to magnesium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0031092	platelet alpha granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0010517	regulation of phospholipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002460	C		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002460	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Paillusson, S et al. (2017) α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production. Acta Neuropathol. PubMed GONUTS page
↑ Wilhelm, BG et al. (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344 1023-8 PubMed GONUTS page
↑ Skibinski, G et al. (2014) Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J. Neurosci. 34 418-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Perez, RG et al. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22 3090-9 PubMed GONUTS page
↑ Alim, MA et al. (2002) Tubulin seeds alpha-synuclein fibril formation. J. Biol. Chem. 277 2112-7 PubMed GONUTS page
↑ Jeannotte, AM et al. (2009) Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum. Neurosci. Lett. 467 86-9 PubMed GONUTS page
↑ Leng, Y & Chuang, DM (2006) Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. J. Neurosci. 26 7502-12 PubMed GONUTS page
↑ Schlossmacher, MG et al. (2002) Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am. J. Pathol. 160 1655-67 PubMed GONUTS page
↑ Jeannotte, AM et al. (2009) Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Neuropsychopharmacology 34 987-98 PubMed GONUTS page
↑ ^10.0 ^10.1 Boyer, F & Dreyer, JL (2007) Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. Eur. J. Neurosci. 26 2764-76 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kim, SJ et al. (2003) Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J. Biol. Chem. 278 41890-9 PubMed GONUTS page
↑ Rideout, HJ et al. (2003) Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. J. Neurochem. 84 803-13 PubMed GONUTS page
↑ Li, J- et al. (2002) Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Neuroscience 113 463-78 PubMed GONUTS page
↑ ^14.0 ^14.1 Monti, B et al. (2007) Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death. J. Neurochem. 103 518-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Ahn, BH et al. (2002) alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J. Biol. Chem. 277 12334-42 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Lee, HJ et al. (2002) Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J. Biol. Chem. 277 671-8 PubMed GONUTS page
↑ Nakajima, T et al. (2005) Alpha-synuclein-positive structures induced in leupeptin-infused rats. Brain Res. 1040 73-80 PubMed GONUTS page
↑ Murphy, DD et al. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20 3214-20 PubMed GONUTS page
↑ Yu, S et al. (2007) Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 145 539-55 PubMed GONUTS page
↑ Brenz Verca, MS et al. (2003) Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. Eur. J. Neurosci. 18 1923-38 PubMed GONUTS page
↑ Quilty, MC et al. (2003) Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma. Exp. Neurol. 182 195-207 PubMed GONUTS page
↑ Tehranian, R et al. (2006) Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J. Neurochem. 99 1188-96 PubMed GONUTS page
↑ Adamczyk, A et al. (2005) Expression of alpha-synuclein in different brain parts of adult and aged rats. J. Physiol. Pharmacol. 56 29-37 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Mori, F et al. (2002) Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. Acta Neuropathol. 103 145-51 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Liu, G et al. (2009) alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci. Lett. 454 187-92 PubMed GONUTS page
↑ Ghee, M et al. (2000) Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. J. Neurochem. 75 2221-4 PubMed GONUTS page
↑ Vivacqua, G et al. (2009) Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies. Neuroscience 158 1478-87 PubMed GONUTS page

[PMID:28337542-1] 1.0 ^1.1 Paillusson, S et al. (2017) α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production. Acta Neuropathol. PubMed GONUTS page

[PMID:24876496-2] Wilhelm, BG et al. (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science 344 1023-8 PubMed GONUTS page

[PMID:24403142-3] Skibinski, G et al. (2014) Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J. Neurosci. 34 418-33 PubMed GONUTS page

[PMID:11943812-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Perez, RG et al. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22 3090-9 PubMed GONUTS page

[PMID:11698390-5] Alim, MA et al. (2002) Tubulin seeds alpha-synuclein fibril formation. J. Biol. Chem. 277 2112-7 PubMed GONUTS page

[PMID:19818834-6] Jeannotte, AM et al. (2009) Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum. Neurosci. Lett. 467 86-9 PubMed GONUTS page

[PMID:16837598-7] Leng, Y & Chuang, DM (2006) Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. J. Neurosci. 26 7502-12 PubMed GONUTS page

[PMID:12000718-8] Schlossmacher, MG et al. (2002) Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am. J. Pathol. 160 1655-67 PubMed GONUTS page

[PMID:18800064-9] Jeannotte, AM et al. (2009) Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Neuropsychopharmacology 34 987-98 PubMed GONUTS page

[PMID:18001274-10] 10.0 ^10.1 Boyer, F & Dreyer, JL (2007) Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. Eur. J. Neurosci. 26 2764-76 PubMed GONUTS page

[PMID:12917442-11] 11.0 ^11.1 ^11.2 Kim, SJ et al. (2003) Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J. Biol. Chem. 278 41890-9 PubMed GONUTS page

[PMID:12562524-12] Rideout, HJ et al. (2003) Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. J. Neurochem. 84 803-13 PubMed GONUTS page

[PMID:12127102-13] Li, J- et al. (2002) Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Neuroscience 113 463-78 PubMed GONUTS page

[PMID:17635667-14] 14.0 ^14.1 Monti, B et al. (2007) Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death. J. Neurochem. 103 518-30 PubMed GONUTS page

[PMID:11821392-15] 15.0 ^15.1 Ahn, BH et al. (2002) alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J. Biol. Chem. 277 12334-42 PubMed GONUTS page

[PMID:11679584-16] 16.0 ^16.1 ^16.2 Lee, HJ et al. (2002) Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J. Biol. Chem. 277 671-8 PubMed GONUTS page

[PMID:15804428-17] Nakajima, T et al. (2005) Alpha-synuclein-positive structures induced in leupeptin-infused rats. Brain Res. 1040 73-80 PubMed GONUTS page

[PMID:10777786-18] Murphy, DD et al. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20 3214-20 PubMed GONUTS page

[PMID:17275196-19] Yu, S et al. (2007) Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 145 539-55 PubMed GONUTS page

[PMID:14622225-20] Brenz Verca, MS et al. (2003) Distribution of alpha- and gamma-synucleins in the adult rat brain and their modification by high-dose cocaine treatment. Eur. J. Neurosci. 18 1923-38 PubMed GONUTS page

[PMID:12821390-21] Quilty, MC et al. (2003) Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma. Exp. Neurol. 182 195-207 PubMed GONUTS page

[PMID:16981894-22] Tehranian, R et al. (2006) Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J. Neurochem. 99 1188-96 PubMed GONUTS page

[PMID:15795473-23] Adamczyk, A et al. (2005) Expression of alpha-synuclein in different brain parts of adult and aged rats. J. Physiol. Pharmacol. 56 29-37 PubMed GONUTS page

[PMID:11810180-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Mori, F et al. (2002) Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. Acta Neuropathol. 103 145-51 PubMed GONUTS page

[PMID:19429081-25] 25.0 ^25.1 ^25.2 ^25.3 Liu, G et al. (2009) alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci. Lett. 454 187-92 PubMed GONUTS page

[PMID:11032911-26] Ghee, M et al. (2000) Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. J. Neurochem. 75 2221-4 PubMed GONUTS page

[PMID:19118601-27] Vivacqua, G et al. (2009) Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies. Neuroscience 158 1478-87 PubMed GONUTS page

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