RAT:RYR1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ryr1
Protein Name(s)	Ryanodine receptor 1 RYR-1 RyR1 Skeletal muscle calcium release channel Skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor Type 1 ryanodine receptor
External Links
UniProt	F1LMY4
EMBL	AF112256 AF130879 AF011788
UniGene	Rn.225306 Rn.87520
ProteinModelPortal	F1LMY4
MINT	MINT-195292
STRING	10116.ENSRNOP00000027893
GuidetoPHARMACOLOGY	747
PhosphoSite	F1LMY4
RGD	1586637
eggNOG	NOG247670
HOGENOM	HOG000231428
HOVERGEN	HBG102939
InParanoid	F1LMY4
OrthoDB	EOG71K622
TreeFam	TF315244
PRO	PR:F1LMY4
Proteomes	UP000002494
GO	GO:0031234 GO:0016021 GO:0042383 GO:0016529 GO:0033017 GO:0005262 GO:0005509 GO:0005219 GO:0005245 GO:0006816 GO:0071313 GO:0051480 GO:0006936 GO:0043931 GO:0003151 GO:0051209 GO:0014808 GO:0031000 GO:0070296 GO:0048741 GO:0043588
Gene3D	1.10.238.10 1.25.10.30
InterPro	IPR001870 IPR013320 IPR011992 IPR014821 IPR005821 IPR016093 IPR013662 IPR000699 IPR013333 IPR003032 IPR015925 IPR009460 IPR003877
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF06459 PF01365 PF02026 PF00622
PRINTS	PR00795
SMART	SM00472 SM00449
SUPFAM	SSF100909 SSF49899 SSF82109
PROSITE	PS50188 PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071318	cellular response to ATP	PMID:11316255^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:11316255^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:11316255^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:11316255^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0014802	terminal cisterna	PMID:11316255^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990425	ryanodine receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	C	Seeded From UniProt	complete
part_of	GO:0031301	integral component of organelle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	C	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	F	Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P	Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P	Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:19116207^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:19116207^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	PMID:19116207^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:19116207^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:19116207^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
involved_in	GO:0043931	ossification involved in bone maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21454501^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	F	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	F	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	F	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9PZQ0	P	Seeded From UniProt	complete
involved_in	GO:0070296	sarcoplasmic reticulum calcium ion transport	PMID:19230144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21474431^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:19593990^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:20177054^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:19230144^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:19230144^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P	Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736	F	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:1586637 RGD:620314	C	Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 UniProtKB:Q92736	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99684 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 UniProtKB:P21817	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C	Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 RGD:620314 UniProtKB:Q92736	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C	Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736 ZFIN:ZDB-GENE-070705-417	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F	Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460 InterPro:IPR013333	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013333 InterPro:IPR015925	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	P	Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033215	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703 UniProtKB-SubCell:SL-0239	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Jóna, I et al. (2001) Altered inhibition of the rat skeletal ryanodine receptor/calcium release channel by magnesium in the presence of ATP. Pflugers Arch. 441 729-38 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rosker, C et al. (2009) Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. J. Biol. Chem. 284 5186-94 PubMed GONUTS page
↑ Ryan, T et al. (2011) Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). J. Biol. Chem. 286 17060-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Duke, AM & Steele, DS (2008) The presence of a functional t-tubule network increases the sensitivity of RyR1 to agonists in skinned rat skeletal muscle fibres. Cell Calcium 44 411-21 PubMed GONUTS page
↑ Kraner, SD et al. (2011) Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R1384-91 PubMed GONUTS page
↑ Zhou, QG et al. (2009) [Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats]. Zhonghua Nan Ke Xue 15 511-6 PubMed GONUTS page
↑ Clark, JH et al. (2010) Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. J. Biol. Chem. 285 13542-9 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11316255-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Jóna, I et al. (2001) Altered inhibition of the rat skeletal ryanodine receptor/calcium release channel by magnesium in the presence of ATP. Pflugers Arch. 441 729-38 PubMed GONUTS page

[PMID:19116207-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rosker, C et al. (2009) Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. J. Biol. Chem. 284 5186-94 PubMed GONUTS page

[PMID:21454501-3] Ryan, T et al. (2011) Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). J. Biol. Chem. 286 17060-8 PubMed GONUTS page

[PMID:19230144-4] 4.0 ^4.1 ^4.2 Duke, AM & Steele, DS (2008) The presence of a functional t-tubule network increases the sensitivity of RyR1 to agonists in skinned rat skeletal muscle fibres. Cell Calcium 44 411-21 PubMed GONUTS page

[PMID:21474431-5] Kraner, SD et al. (2011) Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R1384-91 PubMed GONUTS page

[PMID:19593990-6] Zhou, QG et al. (2009) [Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats]. Zhonghua Nan Ke Xue 15 511-6 PubMed GONUTS page

[PMID:20177054-7] Clark, JH et al. (2010) Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. J. Biol. Chem. 285 13542-9 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:RYR1

Contents

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