RAT:PK3CB

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pik3cb
Protein Name(s)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PI3-kinase subunit beta PI3K-beta PI3Kbeta PtdIns-3-kinase subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta PtdIns-3-kinase subunit p110-beta p110beta
External Links
UniProt	Q9Z1L0
EMBL	AJ012482
RefSeq	NP_445933.1
UniGene	Rn.108166 Rn.44268
ProteinModelPortal	Q9Z1L0
MINT	MINT-204613
STRING	10116.ENSRNOP00000022179
PhosphoSite	Q9Z1L0
PaxDb	Q9Z1L0
PRIDE	Q9Z1L0
GeneID	85243
KEGG	rno:85243
UCSC	RGD:620917
CTD	5291
RGD	620917
eggNOG	KOG0904 COG5032
HOGENOM	HOG000252911
HOVERGEN	HBG052721
InParanoid	Q9Z1L0
KO	K00922
PhylomeDB	Q9Z1L0
BRENDA	2.7.1.153
UniPathway	UPA00220
NextBio	617306
PRO	PR:Q9Z1L0
Proteomes	UP000002494
GO	GO:0031526 GO:0005829 GO:0005634 GO:0005942 GO:0016303 GO:0035005 GO:0005524 GO:0035004 GO:0046934 GO:0006914 GO:0007155 GO:0006897 GO:0046854 GO:0036092 GO:0048015
Gene3D	1.10.1070.11 1.25.40.70 2.60.40.150
InterPro	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR003113 IPR002420 IPR000341 IPR015433 IPR001263 IPR029071
PANTHER	PTHR10048
Pfam	PF00454 PF00792 PF02192 PF00794 PF00613
SMART	SM00142 SM00143 SM00144 SM00145 SM00146
SUPFAM	SSF48371 SSF49562 SSF54236 SSF56112
PROSITE	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0051965	positive regulation of synapse assembly	PMID:21414895^[1]	ECO:0000314			P	Figure 1B shows increase in synapse density after activation of PI3k by PTD4-PI3KAc.	complete CACAO 11245
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:12882977^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	PMID:12395317^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	PMID:11931646^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:12882977^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:11931646^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:12882977^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P	Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203729 MGI:MGI:2685045 PANTHER:PTN000005674 WB:WBGene00009552	P	Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 PANTHER:PTN000005674 RGD:620231	F	Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922019 PANTHER:PTN000799655	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 UniProtKB:O42391	P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 MGI:MGI:1203729 MGI:MGI:1206581 MGI:MGI:1922019 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P42336	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015279 PANTHER:PTN000005674 UniProtKB:O00329 UniProtKB:P42338 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 MGI:MGI:1353576 PANTHER:PTN000799655	P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P32871 WB:WBGene00000090	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 RGD:620231 UniProtKB:O00443 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037702	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290	F	Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037702	F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-912619 Reactome:R-RNO-451755	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cuesto, G et al. (2011) Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31 2721-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kaplan-Albuquerque, N et al. (2003) Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J. Biol. Chem. 278 39830-8 PubMed GONUTS page
↑ Coutant, A et al. (2002) PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology 36 1079-88 PubMed GONUTS page
↑ ^4.0 ^4.1 Crljen, V et al. (2002) Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Biochem. J. 365 791-9 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21414895-1] Cuesto, G et al. (2011) Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31 2721-33 PubMed GONUTS page

[PMID:12882977-2] 2.0 ^2.1 ^2.2 Kaplan-Albuquerque, N et al. (2003) Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J. Biol. Chem. 278 39830-8 PubMed GONUTS page

[PMID:12395317-3] Coutant, A et al. (2002) PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology 36 1079-88 PubMed GONUTS page

[PMID:11931646-4] 4.0 ^4.1 Crljen, V et al. (2002) Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Biochem. J. 365 791-9 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:PK3CB

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