RAT:MCL1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Mcl1
Protein Name(s)	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
External Links
UniProt	Q9Z1P3
EMBL	AF115380 BC078835 AF144096
RefSeq	NP_068618.2
UniGene	Rn.129914 Rn.161889
ProteinModelPortal	Q9Z1P3
SMR	Q9Z1P3
IntAct	Q9Z1P3
MINT	MINT-206606
PhosphoSite	Q9Z1P3
PRIDE	Q9Z1P3
GeneID	60430
KEGG	rno:60430
CTD	4170
RGD	620525
HOVERGEN	HBG003527
InParanoid	Q9Z1P3
KO	K02539
PhylomeDB	Q9Z1P3
NextBio	612150
PRO	PR:Q9Z1P3
Proteomes	UP000002494
Genevestigator	Q9Z1P3
GO	GO:0005829 GO:0016021 GO:0016020 GO:0005739 GO:0005654 GO:0051400 GO:0046983 GO:0046982 GO:0030154 GO:0097192 GO:0007275 GO:0043066
InterPro	IPR013281 IPR002475 IPR020717 IPR020726 IPR020728 IPR026298
PANTHER	PTHR11256 PTHR11256:SF6
Pfam	PF00452
PRINTS	PR01866 PR01862
PROSITE	PS50062 PS01080 PS01258 PS01259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0043066	negative regulation of apoptotic process	PMID:21977009^[1]	ECO:0000315			P	Fig.2a Mcl-1 protein expression by gradually decreases after PIC transfection fig.2d Mcl-1 KO by siRNAs increase cleavage of caspase 3 and 9	complete CACAO 4591
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q07820	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q792S6	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97287	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97287	C	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70984	F	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621635	F	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621547	F	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2192	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70984	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621635	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621547	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2192	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9356461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR026298 InterPro:IPR036834	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Colli, ML et al. (2011) Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. PLoS Pathog. 7 e1002267 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hsu, SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U.S.A. 94 12401-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21977009-1] Colli, ML et al. (2011) Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. PLoS Pathog. 7 e1002267 PubMed GONUTS page

[PMID:9356461-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hsu, SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U.S.A. 94 12401-6 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:MCL1

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