RAT:LRRC7

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Lrrc7 (synonyms: Lap1)
Protein Name(s)	Leucine-rich repeat-containing protein 7 Densin-180 Densin Protein LAP1
External Links
UniProt	P70587
EMBL	U66707 AF266164
PIR	T31434
RefSeq	NP_476483.1
UniGene	Rn.89629
BioGrid	250730
IntAct	P70587
MINT	MINT-1785354
PhosphoSite	P70587
PaxDb	P70587
PRIDE	P70587
GeneID	117284
KEGG	rno:117284
CTD	57554
RGD	708527
eggNOG	COG4886
HOGENOM	HOG000060229
HOVERGEN	HBG052305
InParanoid	P70587
NextBio	620243
PRO	PR:P70587
Proteomes	UP000002494
Genevestigator	P70587
GO	GO:0043194 GO:0030054 GO:0005737 GO:0043197 GO:0030175 GO:0043005 GO:0005886 GO:0014069 GO:0045211 GO:0045202 GO:0008022 GO:0010976 GO:0014070
Gene3D	2.30.42.10
InterPro	IPR001611 IPR025875 IPR001478
Pfam	PF00560 PF12799 PF13855 PF00595
SMART	SM00228
SUPFAM	SSF50156
PROSITE	PS51450 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Colocalizes with	GO:0005789	endoplasmic reticulum membrane	PMID:9182656^[1]	ECO:0000314			C		Figure 2	complete CACAO 10450
colocalizes_with	GO:0005789	endoplasmic reticulum membrane	PMID:9182656^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8824323^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8824323^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8824323^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8824323^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8824323^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8824323^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:8824323^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:8824323^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043194	axon initial segment	PMID:8824323^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:8824323^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:15647492^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:18248607^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	PMID:18248607^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:19038319^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:8824323^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:15647492^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:16120608^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18248607^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18248607^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055	P		Seeded From UniProt	complete
involved_in	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:68424	P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 UniProtKB:Q14160	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:708527	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000568496 RGD:708527	C		Seeded From UniProt	complete
involved_in	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1888986 PANTHER:PTN001501163	P		Seeded From UniProt	complete
part_of	GO:0043194	axon initial segment	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000568496 RGD:708527	C		Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001501163 RGD:619895	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000568496 RGD:708527	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163 RGD:2505 RGD:68423 RGD:68424	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107231 MGI:MGI:1277959 MGI:MGI:1344351 PANTHER:PTN001501163 UniProtKB:Q12959 UniProtKB:Q14160	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263289 MGI:MGI:107231 MGI:MGI:2145950 PANTHER:PTN001501163 RGD:2505 UniProtKB:Q12959 WB:WBGene00002632	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001900149 RGD:1565055 RGD:708527	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000568496 RGD:708527	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000568496 RGD:708527	P		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277959 PANTHER:PTN001501163	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508426 UniProtKB:Q14160	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002508426 RGD:1565055 UniProtKB:Q14160	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yang, L et al. (1997) Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. J. Cell Biol. 137 1199-210 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Apperson, ML et al. (1996) Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J. Neurosci. 16 6839-52 PubMed GONUTS page
↑ ^3.0 ^3.1 Quitsch, A et al. (2005) Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180. J. Neurosci. 25 479-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Jiao, Y et al. (2008) Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. J. Neurochem. 105 1746-60 PubMed GONUTS page
↑ Lin, HM et al. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol. Lett. 184 90-6 PubMed GONUTS page
↑ Robison, AJ et al. (2005) Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J. Biol. Chem. 280 35329-36 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9182656-1] 1.0 ^1.1 Yang, L et al. (1997) Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. J. Cell Biol. 137 1199-210 PubMed GONUTS page

[PMID:8824323-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Apperson, ML et al. (1996) Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J. Neurosci. 16 6839-52 PubMed GONUTS page

[PMID:15647492-3] 3.0 ^3.1 Quitsch, A et al. (2005) Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180. J. Neurosci. 25 479-87 PubMed GONUTS page

[PMID:18248607-4] 4.0 ^4.1 ^4.2 ^4.3 Jiao, Y et al. (2008) Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. J. Neurochem. 105 1746-60 PubMed GONUTS page

[PMID:19038319-5] Lin, HM et al. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol. Lett. 184 90-6 PubMed GONUTS page

[PMID:16120608-6] Robison, AJ et al. (2005) Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J. Biol. Chem. 280 35329-36 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:LRRC7

Contents

Annotations

Notes

References

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