RAT:KCNA3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Kcna3
Protein Name(s)	Potassium voltage-gated channel subfamily A member 3 RCK3 RGK5 Voltage-gated potassium channel subunit Kv1.3 Voltage-gated potassium channel subunit Kv3
External Links
UniProt	P15384
EMBL	X16001 M30312 M31744
PIR	A43531
RefSeq	NP_062143.3
UniGene	Rn.44292
ProteinModelPortal	P15384
SMR	P15384
BioGrid	248344
IntAct	P15384
STRING	10116.ENSRNOP00000024372
ChEMBL	CHEMBL4248
GuidetoPHARMACOLOGY	540
PaxDb	P15384
PRIDE	P15384
Ensembl	ENSRNOT00000024372
GeneID	29731
KEGG	rno:29731
UCSC	RGD:2951
CTD	3738
RGD	2951
eggNOG	COG1226
GeneTree	ENSGT00760000118846
HOGENOM	HOG000231015
HOVERGEN	HBG052230
InParanoid	P15384
KO	K04876
OMA	KRRMRYF
OrthoDB	EOG7M0NRD
PhylomeDB	P15384
TreeFam	TF313103
Reactome	REACT_199159
NextBio	610214
PRO	PR:P15384
Proteomes	UP000002494
ExpressionAtlas	P15384
Genevestigator	P15384
GO	GO:0045121 GO:0005886 GO:0008076 GO:0005251 GO:0015271 GO:0005249 GO:0006813 GO:0051260
Gene3D	1.20.120.350
InterPro	IPR000210 IPR011333 IPR027359 IPR005821 IPR003091 IPR003968 IPR003972 IPR004050 IPR003131 IPR028325
PANTHER	PTHR11537
Pfam	PF02214 PF00520
PRINTS	PR00169 PR01510 PR01491 PR01496
SMART	SM00225
SUPFAM	SSF54695

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	PMID:2555158^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:2555158^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:2555158^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:18218624^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18218624^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:14614103^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0044305)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:14614103^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:14614103^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0044305)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:14614103^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:14614103^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:14602579^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:14602579^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002479980 UniProtKB:P22460	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102663 MGI:MGI:1336181 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96666 PANTHER:PTN000164970 RGD:2949 RGD:2950 RGD:2951 RGD:2952 RGD:2953 RGD:2954 RGD:2955 RGD:62083 RGD:621349 RGD:621504 RGD:628829 RGD:631416 RGD:68393 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P17658 UniProtKB:P22459 UniProtKB:P22460 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q14721 UniProtKB:Q8TAE7 UniProtKB:Q8TDN1 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 UniProtKB:Q9UIX4 WB:WBGene00001374 WB:WBGene00014261	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96660 PANTHER:PTN000165753	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003380 FB:FBgn0033494 PANTHER:PTN000164970 RGD:2952	C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002479980 RGD:2951 RGD:2953 UniProtKB:P22460	F		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003380 MGI:MGI:102663 MGI:MGI:1197011 MGI:MGI:1197019 MGI:MGI:1309503 MGI:MGI:1336181 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96666 PANTHER:PTN001355853 RGD:2949 RGD:2950 RGD:2952 RGD:2953 RGD:2954 RGD:2955 RGD:62083 RGD:621349 RGD:621503 RGD:621504 RGD:628829 RGD:631416 RGD:68393 RGD:68394 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P22459 UniProtKB:P22460 UniProtKB:P48547 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q14721 UniProtKB:Q8TAE7 UniProtKB:Q8TDN1 UniProtKB:Q96KK3 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 UniProtKB:Q9UIX4 UniProtKB:Q9UK17	C		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96654 PANTHER:PTN000898862 RGD:2949 RGD:2950 RGD:2951 RGD:2953 RGD:62083 UniProtKB:P17658 UniProtKB:P22460 UniProtKB:Q09470 WB:WBGene00014261	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108083 MGI:MGI:1924937 MGI:MGI:1926803 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96662 PANTHER:PTN000164970 RGD:2949 RGD:2950 RGD:2951 RGD:2952 RGD:2954 RGD:621504 RGD:628829 RGD:628832 RGD:628848 RGD:68393 RGD:68394 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P22459 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 WB:WBGene00004793 ZFIN:ZDB-GENE-030131-5626	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16390 ensembl:ENSMUSP00000050680	C		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003968 InterPro:IPR003972 InterPro:IPR004050 InterPro:IPR028325	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003968 InterPro:IPR003972 InterPro:IPR004050 InterPro:IPR028325	P		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003968 InterPro:IPR003972 InterPro:IPR004050 InterPro:IPR028325	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003131	P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	PMID:2351830^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:2351830^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Stühmer, W et al. (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 8 3235-44 PubMed GONUTS page
↑ ^2.0 ^2.1 Vicente, R et al. (2008) Kv1.5 association modifies Kv1.3 traffic and membrane localization. J. Biol. Chem. 283 8756-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ishikawa, T et al. (2003) Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. J. Neurosci. 23 10445-53 PubMed GONUTS page
↑ ^4.0 ^4.1 Speake, T et al. (2004) Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells. Am. J. Physiol., Cell Physiol. 286 C611-20 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Douglass, J et al. (1990) Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. J. Immunol. 144 4841-50 PubMed GONUTS page

[PMID:2555158-1] 1.0 ^1.1 ^1.2 Stühmer, W et al. (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 8 3235-44 PubMed GONUTS page

[PMID:18218624-2] 2.0 ^2.1 Vicente, R et al. (2008) Kv1.5 association modifies Kv1.3 traffic and membrane localization. J. Biol. Chem. 283 8756-64 PubMed GONUTS page

[PMID:14614103-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ishikawa, T et al. (2003) Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. J. Neurosci. 23 10445-53 PubMed GONUTS page

[PMID:14602579-4] 4.0 ^4.1 Speake, T et al. (2004) Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells. Am. J. Physiol., Cell Physiol. 286 C611-20 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2351830-6] 6.0 ^6.1 Douglass, J et al. (1990) Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. J. Immunol. 144 4841-50 PubMed GONUTS page

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RAT:KCNA3

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Annotations

Notes

References

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