RAT:K6PF

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pfkm (synonyms: Pfk-m)
Protein Name(s)	6-phosphofructokinase, muscle type Phosphofructo-1-kinase isozyme A PFK-A Phosphofructokinase-M Phosphofructokinase 1 Phosphohexokinase
External Links
UniProt	P47858
EMBL	U25651 D21869
PIR	S71429
RefSeq	NP_113903.1
UniGene	Rn.11004
ProteinModelPortal	P47858
BioGrid	249268
IntAct	P47858
MINT	MINT-89284
PhosphoSite	P47858
PaxDb	P47858
PRIDE	P47858
GeneID	65152
KEGG	rno:65152
UCSC	RGD:68419
CTD	5213
RGD	68419
eggNOG	COG0205
HOGENOM	HOG000200154
HOVERGEN	HBG000976
InParanoid	P47858
KO	K00850
PhylomeDB	P47858
SABIO-RK	P47858
UniPathway	UPA00109
NextBio	613989
Genevestigator	P47858
GO	GO:0005945 GO:0003872 GO:0016208 GO:0005524 GO:0030246 GO:0070095 GO:0046872 GO:0008443 GO:0046835 GO:0001678 GO:0030388 GO:0006002 GO:0006096 GO:0051289
HAMAP	MF_00339
InterPro	IPR009161 IPR022953 IPR015912 IPR000023
Pfam	PF00365
PIRSF	PIRSF000533
PRINTS	PR00476
SUPFAM	SSF53784
TIGRFAMs	TIGR02478
PROSITE	PS00433

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0003872	6-phosphofructokinase activity	PMID:3157684^[1]	ECO:0000314			F	See figure 2 for phosphofructokinase activity.	complete CACAO 6240
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00511	F	Seeded From UniProt	complete
enables	GO:0070095	fructose-6-phosphate binding	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070095	fructose-6-phosphate binding	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070095	fructose-6-phosphate binding	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:8593533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	PMID:8593533^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016208	AMP binding	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016208	AMP binding	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008443	phosphofructokinase activity	PMID:14522413^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008443	phosphofructokinase activity	PMID:8764833^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:8593533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:8593533^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:8593533^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:3159721^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:2931076^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:12161^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:8764833^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070095	fructose-6-phosphate binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P17858	F	Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97548 PANTHER:PTN000344216	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 RGD:3311 RGD:61893 RGD:68419	P	Seeded From UniProt	complete
enables	GO:0048029	monosaccharide binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 RGD:3311	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 MGI:MGI:97548 PANTHER:PTN000344216 UniProtKB:P08237 UniProtKB:P17858 UniProtKB:Q01813	F	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P17858	P	Seeded From UniProt	complete
enables	GO:0016208	AMP binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 RGD:68419	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344223 UniProtKB:P08237	C	Seeded From UniProt	complete
involved_in	GO:0006007	glucose catabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 dictyBase:DDB_G0274111	P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97547 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:P17858 dictyBase:DDB_G0274111	P	Seeded From UniProt	complete
part_of	GO:0005945	6-phosphofructokinase complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 PomBase:SPBC16H5.02 SGD:S000003472 SGD:S000004818 UniProtKB:P08237 UniProtKB:P17858 dictyBase:DDB_G0274111	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:P17858	F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 FB:FBgn0003071 MGI:MGI:97548 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:Q01813 dictyBase:DDB_G0274111	F	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008443	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008443	P	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000023 InterPro:IPR009161 InterPro:IPR015912 InterPro:IPR022953 InterPro:IPR035966	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009161	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009161	C	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022953	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000023 InterPro:IPR009161 InterPro:IPR015912 InterPro:IPR022953 InterPro:IPR035966	P	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.11	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	C	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Choate, GL et al. (1985) Heart 6-phosphofructo-1-kinase. Subcellular distribution and binding to myofibrils. J. Biol. Chem. 260 4815-22 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tornheim, K (1985) Activation of muscle phosphofructokinase by fructose 2,6-bisphosphate and fructose 1,6-bisphosphate is differently affected by other regulatory metabolites. J. Biol. Chem. 260 7985-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Vora, S et al. (1985) Isoenzymes of phosphofructokinase in the rat. Demonstration of the three non-identical subunits by biochemical, immunochemical and kinetic studies. Biochem. J. 229 333-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Tornheim, K & Lowenstein, JM (1976) Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. J. Biol. Chem. 251 7322-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Chen-Zion, M et al. (1995) Rapid changes in carbohydrate metabolism in muscle induced by triiodothyronine; the role of glucose 1,6-bisphosphate. Biochem. Mol. Med. 56 19-25 PubMed GONUTS page
↑ Tessier, JP et al. (2003) Impairment of glucose metabolism in hearts from rats treated with endotoxin. Cardiovasc. Res. 60 119-30 PubMed GONUTS page
↑ ^7.0 ^7.1 Ma, Z et al. (1996) Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform. Biochim. Biophys. Acta 1308 151-63 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:3157684-1] Choate, GL et al. (1985) Heart 6-phosphofructo-1-kinase. Subcellular distribution and binding to myofibrils. J. Biol. Chem. 260 4815-22 PubMed GONUTS page

[PMID:3159721-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tornheim, K (1985) Activation of muscle phosphofructokinase by fructose 2,6-bisphosphate and fructose 1,6-bisphosphate is differently affected by other regulatory metabolites. J. Biol. Chem. 260 7985-9 PubMed GONUTS page

[PMID:2931076-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Vora, S et al. (1985) Isoenzymes of phosphofructokinase in the rat. Demonstration of the three non-identical subunits by biochemical, immunochemical and kinetic studies. Biochem. J. 229 333-41 PubMed GONUTS page

[PMID:12161-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Tornheim, K & Lowenstein, JM (1976) Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. J. Biol. Chem. 251 7322-8 PubMed GONUTS page

[PMID:8593533-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Chen-Zion, M et al. (1995) Rapid changes in carbohydrate metabolism in muscle induced by triiodothyronine; the role of glucose 1,6-bisphosphate. Biochem. Mol. Med. 56 19-25 PubMed GONUTS page

[PMID:14522413-6] Tessier, JP et al. (2003) Impairment of glucose metabolism in hearts from rats treated with endotoxin. Cardiovasc. Res. 60 119-30 PubMed GONUTS page

[PMID:8764833-7] 7.0 ^7.1 Ma, Z et al. (1996) Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform. Biochim. Biophys. Acta 1308 151-63 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:K6PF

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