RAT:GRM1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Grm1 (synonyms: Gprc1a, Mglur1)
Protein Name(s)	Metabotropic glutamate receptor 1 mGluR1
External Links
UniProt	P23385
EMBL	X57569 M61099 S48085
PIR	A41939
RefSeq	NP_001107802.1 NP_058707.1
UniGene	Rn.87787
PDB	1EWK 1EWT 1EWV 1ISR 1ISS
PDBsum	1EWK 1EWT 1EWV 1ISR 1ISS
ProteinModelPortal	P23385
SMR	P23385
BioGrid	246579
DIP	DIP-44897N
IntAct	P23385
MINT	MINT-1890098
BindingDB	P23385
ChEMBL	CHEMBL2111335
GuidetoPHARMACOLOGY	289
PhosphoSite	P23385
PaxDb	P23385
PRIDE	P23385
GeneID	24414
KEGG	rno:24414
UCSC	RGD:2742
CTD	2911
RGD	2742
eggNOG	NOG295200
HOGENOM	HOG000218636
HOVERGEN	HBG107965
InParanoid	P23385
KO	K04603
PhylomeDB	P23385
EvolutionaryTrace	P23385
NextBio	603247
PMAP-CutDB	P23385
PRO	PR:P23385
Proteomes	UP000002494
Genevestigator	P23385
GO	GO:0030424 GO:0043197 GO:0005887 GO:0014069 GO:0042734 GO:0030331 GO:0004930 GO:0008066 GO:0042802 GO:0001639 GO:0019722 GO:0038042 GO:0007216 GO:0007186 GO:0051899 GO:0007206 GO:0051482 GO:0007205 GO:0014048 GO:0051966 GO:0019233 GO:0007268 GO:0051932
InterPro	IPR001828 IPR000337 IPR011500 IPR017978 IPR017979 IPR000162 IPR001256 IPR019588 IPR028082
Pfam	PF00003 PF01094 PF10606 PF07562
PRINTS	PR00248 PR01051 PR00593
SUPFAM	SSF53822
PROSITE	PS00979 PS00980 PS00981 PS50259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:14614461^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0000121) has_start_location:(GO:0045211)	Seeded From UniProt	complete
enables	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	PMID:14614461^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:0000121)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:9412905^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000121)	Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13255	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13255	C		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13255	F		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13255	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13255	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:11530226^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:11530226^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11530226^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8104433^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:18582438^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:18948402^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:15229243^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:12514201^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:18582438^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:11226670^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:12514201^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351338 MGI:MGI:1351342 PANTHER:PTN002514246	F		Seeded From UniProt	complete
enables	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351342 PANTHER:PTN002514246 RGD:2742	F		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002514246 RGD:2742 RGD:2746	C		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742	P		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:A0A0B4KF15 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F		Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742 RGD:2746 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000206 FB:FBgn0019985 PANTHER:PTN001173583 RGD:619858 UniProtKB:A0A0B4KF15 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14833	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19590495^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23385	F		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099530	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099530	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099583	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000337 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000337 InterPro:IPR001256 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000337 InterPro:IPR001256 InterPro:IPR017978 InterPro:IPR017979	C		Seeded From UniProt	complete
involved_in	GO:0051932	synaptic transmission, GABAergic	PMID:11530226^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	PMID:12514208^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:12514208^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014048	regulation of glutamate secretion	PMID:11530226^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007206	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	PMID:12514208^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001639	PLC activating G protein-coupled glutamate receptor activity	PMID:12514208^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:12514201^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:12562994^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:12514201^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kim, SJ et al. (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426 285-91 PubMed GONUTS page
↑ Luján, R et al. (1997) Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J. Chem. Neuroanat. 13 219-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wittmann, M et al. (2001) Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Neuroscience 105 881-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Baude, A et al. (1993) The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11 771-87 PubMed GONUTS page
↑ ^5.0 ^5.1 Agassandian, K & Cassell, MD (2008) Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Brain Res. 1226 39-55 PubMed GONUTS page
↑ Kuo, J et al. (2009) Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology 150 1369-76 PubMed GONUTS page
↑ Kushmerick, C et al. (2004) Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J. Neurosci. 24 5955-65 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Neugebauer, V et al. (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J. Neurosci. 23 52-63 PubMed GONUTS page
↑ Wyneken, U et al. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102 65-74 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rives, ML et al. (2009) Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J. 28 2195-208 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Poisik, OV et al. (2003) Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J. Neurosci. 23 122-30 PubMed GONUTS page
↑ Gee, CE et al. (2003) Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus. J. Physiol. (Lond.) 546 655-64 PubMed GONUTS page

[PMID:14614461-1] 1.0 ^1.1 Kim, SJ et al. (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426 285-91 PubMed GONUTS page

[PMID:9412905-2] Luján, R et al. (1997) Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J. Chem. Neuroanat. 13 219-41 PubMed GONUTS page

[PMID:11530226-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wittmann, M et al. (2001) Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Neuroscience 105 881-9 PubMed GONUTS page

[PMID:8104433-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Baude, A et al. (1993) The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11 771-87 PubMed GONUTS page

[PMID:18582438-5] 5.0 ^5.1 Agassandian, K & Cassell, MD (2008) Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Brain Res. 1226 39-55 PubMed GONUTS page

[PMID:18948402-6] Kuo, J et al. (2009) Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology 150 1369-76 PubMed GONUTS page

[PMID:15229243-7] Kushmerick, C et al. (2004) Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J. Neurosci. 24 5955-65 PubMed GONUTS page

[PMID:12514201-8] 8.0 ^8.1 ^8.2 ^8.3 Neugebauer, V et al. (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J. Neurosci. 23 52-63 PubMed GONUTS page

[PMID:11226670-9] Wyneken, U et al. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102 65-74 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19590495-11] Rives, ML et al. (2009) Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J. 28 2195-208 PubMed GONUTS page

[PMID:12514208-12] 12.0 ^12.1 ^12.2 ^12.3 Poisik, OV et al. (2003) Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J. Neurosci. 23 122-30 PubMed GONUTS page

[PMID:12562994-13] Gee, CE et al. (2003) Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus. J. Physiol. (Lond.) 546 655-64 PubMed GONUTS page

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RAT:GRM1

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Annotations

Notes

References

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