RAT:GPNMB

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gpnmb
Protein Name(s)	Transmembrane glycoprotein NMB
External Links
UniProt	Q6P7C7
EMBL	BC061725
UniGene	Rn.13778
STRING	10116.ENSRNOP00000011945
PaxDb	Q6P7C7
PRIDE	Q6P7C7
Ensembl	ENSRNOT00000011945
UCSC	RGD:71008
RGD	71008
eggNOG	NOG40272
GeneTree	ENSGT00530000063573
HOGENOM	HOG000252941
HOVERGEN	HBG051797
InParanoid	Q6P7C7
OMA	HTYVLNG
OrthoDB	EOG7GXPB9
PhylomeDB	Q6P7C7
TreeFam	TF334865
PRO	PR:Q6P7C7
Proteomes	UP000002494
Genevestigator	Q6P7C7
GO	GO:0005887 GO:0042470 GO:0008201 GO:0030282 GO:0007155 GO:0001649
Gene3D	2.60.40.670
InterPro	IPR022409 IPR000601
Pfam	PF00801
SMART	SM00089
SUPFAM	SSF49299
PROSITE	PS50093

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050727	regulation of inflammatory response	PMID:22574278^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Figures 4, 6-8	complete CACAO 5104
involved_in	GO:0030282	bone mineralization	PMID:11746512^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:11746512^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1934765 PANTHER:PTN000221105	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1934765 PANTHER:PTN000933229	C	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1934765 PANTHER:PTN000221105	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P	Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0050868	negative regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	F	Seeded From UniProt	complete
enables	GO:0045545	syndecan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	F	Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0034103	regulation of tissue remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	F	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14956 ensembl:ENSP00000371420	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	P	Seeded From UniProt	complete
involved_in	GO:0034103	regulation of tissue remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	P	Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	C	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99P91 ensembl:ENSMUSP00000031840	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0033162	melanosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0160	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Huang, JJ et al. (2012) Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats. Brain Behav 2 85-96 PubMed GONUTS page
↑ ^2.0 ^2.1 Safadi, FF et al. (2001) Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts. J. Cell. Biochem. 84 12-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22574278-1] Huang, JJ et al. (2012) Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats. Brain Behav 2 85-96 PubMed GONUTS page

[PMID:11746512-2] 2.0 ^2.1 Safadi, FF et al. (2001) Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts. J. Cell. Biochem. 84 12-26 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:GPNMB

Contents

Annotations

Notes

References

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