RAT:GPER

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gper (synonyms: Cmkrl2, Gpr30, Gpr41)
Protein Name(s)	G-protein coupled estrogen receptor 1 Chemoattractant receptor-like 2 G-protein coupled receptor 30 G-protein coupled receptor 41 Membrane estrogen receptor mER
External Links
UniProt	O08878
EMBL	U92802
IPI	IPI00196618
PIR	JC5509
RefSeq	NP_598257.1
UniGene	Rn.9806
ProteinModelPortal	O08878
STRING	10116.ENSRNOP00000001732
PRIDE	O08878
GeneID	171104
KEGG	rno:171104
UCSC	RGD:619845
CTD	2852
RGD	619845
eggNOG	NOG151076
HOGENOM	HOG000013114
HOVERGEN	HBG005351
InParanoid	O08878
KO	K04246
OrthoDB	EOG43TZVP
NextBio	621790
PRO	PR:O08878
Genevestigator	O08878
GO	GO:0030659 GO:0005769 GO:0005783 GO:0005789 GO:0005794 GO:0000139 GO:0016021 GO:0045095 GO:0005635 GO:0048471 GO:0005886 GO:0055037 GO:0005802 GO:0008144 GO:0030284 GO:0004930 GO:0042562 GO:0017082 GO:0005496 GO:0030263 GO:0071392 GO:0071333 GO:0071389 GO:0071375 GO:0071356 GO:0007204 GO:0008285 GO:0051053 GO:0010629 GO:0050728 GO:0002695 GO:0030264 GO:0010579 GO:0030335 GO:0008284 GO:0043280 GO:2000353 GO:0045742 GO:0070374 GO:0090004 GO:2001238 GO:0045745 GO:0032962 GO:0032024 GO:0050769 GO:0014068 GO:0001934 GO:0090200 GO:0051281 GO:0045944 GO:0070474 GO:0045909
InterPro	IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007165	signal transduction	PMID:20445128^[1]	ECO:0000316		UniProtKB:O08878	P	FIG. 5. Signaling pathways involved in MAPK3/1 phosphorylation induced by G-1 in the Sertoli cells.	complete CACAO 10522
enables	GO:1990239	steroid hormone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	F	Seeded From UniProt	complete
enables	GO:1990239	steroid hormone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0F9W3	F	Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:23822769^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0071389	cellular response to mineralocorticoid stimulus	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0070474	positive regulation of uterine smooth muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7EQ49	P	Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0051055	negative regulation of lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0051053	negative regulation of DNA metabolic process	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
part_of	GO:0048786	presynaptic active zone	PMID:23822769^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7EQ49	P	Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0044327	dendritic spine head	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:23822769^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:23822769^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	PMID:23822769^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030263	apoptotic chromosome condensation	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019228	neuronal action potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7EQ49	P	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:23907461^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22919059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BMP4	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	C	Seeded From UniProt	complete
involved_in	GO:0002695	negative regulation of leukocyte activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0001956	positive regulation of neurotransmitter secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F7EQ49	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:23283935^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20445128^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19717735^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	PMID:20445128^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:22975889^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042562	hormone binding	PMID:20445128^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030518	intracellular steroid hormone receptor signaling pathway	PMID:20445128^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:19717735^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:19717735^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18489713^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005496	steroid binding	PMID:20445128^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:20445128^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924104 PANTHER:PTN000658977 RGD:619845 UniProtKB:F7EQ49 UniProtKB:Q99527	P	Seeded From UniProt	complete
involved_in	GO:0030518	intracellular steroid hormone receptor signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658977 RGD:619845 UniProtKB:Q99527	P	Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924104 PANTHER:PTN000658977 RGD:619845 UniProtKB:Q99527	F	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658977 RGD:619845 UniProtKB:Q99527	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0285	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Lucas, TF et al. (2010) Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Biol. Reprod. 83 307-17 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Chimento, A et al. (2013) Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Cell Death Dis 4 e747 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gros, R et al. (2013) Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation. Am. J. Physiol., Cell Physiol. 304 C532-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Srivastava, DP & Evans, PD (2013) G-protein oestrogen receptor 1: trials and tribulations of a membrane oestrogen receptor. J. Neuroendocrinol. 25 1219-30 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Almey, A et al. (2012) Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. Endocrinology 153 5373-83 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Deschamps, AM & Murphy, E (2009) Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Am. J. Physiol. Heart Circ. Physiol. 297 H1806-13 PubMed GONUTS page
↑ Hu, R et al. (2012) G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Crit. Care Med. 40 3230-7 PubMed GONUTS page
↑ Alyea, RA et al. (2008) The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. J. Neurochem. 106 1525-33 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20445128-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Lucas, TF et al. (2010) Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Biol. Reprod. 83 307-17 PubMed GONUTS page

[PMID:23907461-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Chimento, A et al. (2013) Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Cell Death Dis 4 e747 PubMed GONUTS page

[PMID:23283935-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gros, R et al. (2013) Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation. Am. J. Physiol., Cell Physiol. 304 C532-40 PubMed GONUTS page

[PMID:23822769-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Srivastava, DP & Evans, PD (2013) G-protein oestrogen receptor 1: trials and tribulations of a membrane oestrogen receptor. J. Neuroendocrinol. 25 1219-30 PubMed GONUTS page

[PMID:22919059-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Almey, A et al. (2012) Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. Endocrinology 153 5373-83 PubMed GONUTS page

[PMID:19717735-6] 6.0 ^6.1 ^6.2 Deschamps, AM & Murphy, E (2009) Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Am. J. Physiol. Heart Circ. Physiol. 297 H1806-13 PubMed GONUTS page

[PMID:22975889-7] Hu, R et al. (2012) G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Crit. Care Med. 40 3230-7 PubMed GONUTS page

[PMID:18489713-8] Alyea, RA et al. (2008) The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. J. Neurochem. 106 1525-33 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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