RAT:GPAT1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gpam (synonyms: Gpat1)
Protein Name(s)	Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAT-1
External Links
UniProt	P97564
EMBL	AF021348 U36771
RefSeq	NP_058970.1
UniGene	Rn.44456
ProteinModelPortal	P97564
PhosphoSite	P97564
PaxDb	P97564
PRIDE	P97564
GeneID	29653
KEGG	rno:29653
UCSC	RGD:61847
CTD	57678
RGD	61847
eggNOG	COG2937
HOGENOM	HOG000112780
InParanoid	P97564
KO	K00629
PhylomeDB	P97564
BRENDA	2.3.1.15
SABIO-RK	P97564
UniPathway	UPA00557
NextBio	609941
PRO	PR:P97564
Proteomes	UP000002494
Genevestigator	P97564
GO	GO:0016021 GO:0031966 GO:0005741 GO:0005739 GO:0005886 GO:0004366 GO:0016024 GO:0032869 GO:0010867 GO:0014823 GO:0046686 GO:0009750 GO:0031667
InterPro	IPR022284 IPR028354 IPR002123
PANTHER	PTHR12563
Pfam	PF01553
PIRSF	PIRSF500064 PIRSF000437
SMART	SM00563

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0046686	response to cadmium ion	PMID:17066326^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:18167308^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:18167308^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:18493788^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:16234267^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:15598672^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	PMID:19053045^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:17493869^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	PMID:10446428^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000285763 RGD:61847	C	Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684962 PANTHER:PTN000285868 UniProtKB:Q9HCL2	P	Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10740 PANTHER:PTN000285868	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10740 MGI:MGI:109162 PANTHER:PTN000285868	P	Seeded From UniProt	complete
involved_in	GO:0006072	glycerol-3-phosphate metabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684962 PANTHER:PTN000285868	P	Seeded From UniProt	complete
enables	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10740 MGI:MGI:109162 MGI:MGI:2684962 PANTHER:PTN000285868 RGD:61847 UniProtKB:Q6NUI2 UniProtKB:Q9HCL2	F	Seeded From UniProt	complete
enables	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028354	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028354	C	Seeded From UniProt	complete
enables	GO:0008374	O-acyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022284	F	Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028354	P	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002123	F	Seeded From UniProt	complete
involved_in	GO:0044255	cellular lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022284	P	Seeded From UniProt	complete
enables	GO:0102420	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.15	F	Seeded From UniProt	complete
enables	GO:0004366	glycerol-3-phosphate O-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.15	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10446428^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0594	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016024	CDP-diacylglycerol biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00557	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Alvarez, SM et al. (2007) Effects of chronic exposure to cadmium on prostate lipids and morphology. Biometals 20 727-41 PubMed GONUTS page
↑ ^2.0 ^2.1 Bronnikov, GE et al. (2008) Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes. Biochem. Biophys. Res. Commun. 367 201-7 PubMed GONUTS page
↑ Palou, M et al. (2008) Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. Pflugers Arch. 456 825-36 PubMed GONUTS page
↑ Kump, DS et al. (2006) Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running. Am. J. Physiol. Endocrinol. Metab. 290 E480-9 PubMed GONUTS page
↑ Lewin, TM et al. (2005) Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes. Am. J. Physiol. Endocrinol. Metab. 288 E835-44 PubMed GONUTS page
↑ Rodríguez-Calvo, R et al. (2009) Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A. Hepatology 49 106-15 PubMed GONUTS page
↑ Pellon-Maison, M et al. (2007) Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Biochim. Biophys. Acta 1771 830-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Ganesh Bhat, B et al. (1999) Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein. Biochim. Biophys. Acta 1439 415-23 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17066326-1] Alvarez, SM et al. (2007) Effects of chronic exposure to cadmium on prostate lipids and morphology. Biometals 20 727-41 PubMed GONUTS page

[PMID:18167308-2] 2.0 ^2.1 Bronnikov, GE et al. (2008) Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes. Biochem. Biophys. Res. Commun. 367 201-7 PubMed GONUTS page

[PMID:18493788-3] Palou, M et al. (2008) Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. Pflugers Arch. 456 825-36 PubMed GONUTS page

[PMID:16234267-4] Kump, DS et al. (2006) Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running. Am. J. Physiol. Endocrinol. Metab. 290 E480-9 PubMed GONUTS page

[PMID:15598672-5] Lewin, TM et al. (2005) Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes. Am. J. Physiol. Endocrinol. Metab. 288 E835-44 PubMed GONUTS page

[PMID:19053045-6] Rodríguez-Calvo, R et al. (2009) Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A. Hepatology 49 106-15 PubMed GONUTS page

[PMID:17493869-7] Pellon-Maison, M et al. (2007) Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Biochim. Biophys. Acta 1771 830-8 PubMed GONUTS page

[PMID:10446428-8] 8.0 ^8.1 Ganesh Bhat, B et al. (1999) Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein. Biochim. Biophys. Acta 1439 415-23 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:GPAT1

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