RAT:GHRL

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ghrl
Protein Name(s)	Appetite-regulating hormone Growth hormone secretagogue Growth hormone-releasing peptide Motilin-related peptide Ghrelin Obestatin-23 Obestatin-13
External Links
UniProt	Q9QYH7
EMBL	AB029433 AB035699
PIR	B59316
RefSeq	NP_067701.1
UniGene	Rn.42103
PhosphoSite	Q9QYH7
PaxDb	Q9QYH7
Ensembl	ENSRNOT00000014103
GeneID	59301
KEGG	rno:59301
UCSC	RGD:632283
CTD	51738
RGD	632283
eggNOG	NOG45924
GeneTree	ENSGT00390000004064
HOGENOM	HOG000236303
HOVERGEN	HBG018522
InParanoid	Q9QYH7
KO	K05254
OMA	EIQFNAP
OrthoDB	EOG741Z4K
PhylomeDB	Q9QYH7
TreeFam	TF336219
Reactome	REACT_250028 REACT_250291 REACT_263374
NextBio	611837
PRO	PR:Q9QYH7
Proteomes	UP000002494
Genevestigator	Q9QYH7
GO	GO:0030424 GO:0005737 GO:0005576 GO:0005615 GO:0001664 GO:0031768 GO:0016608 GO:0005179 GO:0030296 GO:0008154 GO:0000187 GO:0008343 GO:0046697 GO:0016358 GO:0007186 GO:0001696 GO:0043066 GO:0042322 GO:0001937 GO:0050728 GO:0046676 GO:0032691 GO:0045409 GO:0040013 GO:0042536 GO:0032100 GO:0046010 GO:0051461 GO:0051464 GO:0007204 GO:0060124 GO:0032024 GO:0032097 GO:0051965 GO:0042127 GO:0060079 GO:0032095 GO:0043627 GO:0009725
InterPro	IPR006737 IPR006738 IPR005441
PANTHER	PTHR14122
Pfam	PF04643 PF04644
PRINTS	PR01624

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060124	positive regulation of growth hormone secretion	PMID:10604470^[1]	ECO:0000314			P		Figure 5a shows effect of ghrelin on growth hormone secretion.	complete CACAO 10412
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:19666521^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:10604470^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0-1	P		Seeded From UniProt	complete
involved_in	GO:0008343	adult feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQX0-1	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17543279^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:11756331^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:10604470^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:11756331^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10604470^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10604470^[1]	ECO:0000305	curator inference used in manual assertion	GO:0016608	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	PMID:17705669^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:10604470^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O08725	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:22516464^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:22516464^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:26153524^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:26153524^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:26153524^[7]	ECO:0006039	genetically encoded fluorescent electrophysiology assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:26153524^[7]	ECO:0006039	genetically encoded fluorescent electrophysiology assay evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:26153524^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22516464^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:26153524^[7]	ECO:0006039	genetically encoded fluorescent electrophysiology assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22516464^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:26153524^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:26153524^[7]	ECO:0006039	genetically encoded fluorescent electrophysiology assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000253	positive regulation of feeding behavior	PMID:17033095^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	PMID:21642627^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905333	regulation of gastric motility	PMID:23525979^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904468	negative regulation of tumor necrosis factor secretion	PMID:19620309^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904349	positive regulation of small intestine smooth muscle contraction	PMID:21874246^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904349	positive regulation of small intestine smooth muscle contraction	PMID:15890336^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904346	positive regulation of gastric mucosal blood circulation	PMID:17033095^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	PMID:15890336^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	PMID:14551228^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904000	positive regulation of eating behavior	PMID:14551228^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:21642627^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903012	positive regulation of bone development	PMID:12960077^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120058	positive regulation of small intestinal transit	PMID:21874246^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051969	regulation of transmission of nerve impulse	PMID:23525979^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	PMID:23525979^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045927	positive regulation of growth	PMID:12960077^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040010	positive regulation of growth rate	PMID:17033095^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:16647196^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035483	gastric emptying	PMID:15890336^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	PMID:19620309^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	PMID:15994217^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032097	positive regulation of response to food	PMID:17065340^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	PMID:17065340^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:17109695^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:26512025^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:17060681^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15155262^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:17109695^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q8AV73	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q8AV73 UniProtKB:Q9GKY5 UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	PMID:17130496^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0040013	negative regulation of locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051464	positive regulation of cortisol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051461	positive regulation of corticotropin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	F		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006737 InterPro:IPR006738	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441 InterPro:IPR006737 InterPro:IPR006738	C		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-RNO-947656	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kojima, M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-60 PubMed GONUTS page
↑ Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page
↑ Yang, M et al. (2007) Ghrelin inhibits apoptosis signal-regulating kinase 1 activity via upregulating heat-shock protein 70. Biochem. Biophys. Res. Commun. 359 373-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Date, Y et al. (2002) Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 51 124-9 PubMed GONUTS page
↑ Bilgin, HM et al. (2008) Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats. Physiol Res 57 563-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Berrout, L & Isokawa, M (2012) Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Neurosci. Lett. 516 280-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Cavalier, M et al. (2015) Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus. Eur. J. Neurosci. 42 2568-76 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Warzecha, Z et al. (2006) Influence of ghrelin on gastric and duodenal growth and expression of digestive enzymes in young mature rats. J. Physiol. Pharmacol. 57 425-37 PubMed GONUTS page
↑ ^9.0 ^9.1 Zaniolo, K et al. (2011) Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest. Ophthalmol. Vis. Sci. 52 5376-86 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gong, Y et al. (2014) Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation. J. Gastroenterol. 49 219-30 PubMed GONUTS page
↑ ^11.0 ^11.1 Theil, MM et al. (2009) Suppression of experimental autoimmune encephalomyelitis by ghrelin. J. Immunol. 183 2859-66 PubMed GONUTS page
↑ ^12.0 ^12.1 Yang, CG et al. () Down-regulation of ghrelin receptors in the small intestine delays small intestinal transit in vagotomized rats. Mol Med Rep 4 1061-5 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Depoortere, I et al. (2005) Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur. J. Pharmacol. 515 160-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Thompson, NM et al. (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 234-42 PubMed GONUTS page
↑ ^15.0 ^15.1 Thompson, NM et al. (2003) Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. Endocrinology 144 4859-67 PubMed GONUTS page
↑ Gauna, C et al. (2006) Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol. Cell. Endocrinol. 251 103-11 PubMed GONUTS page
↑ Kobelt, P et al. (2006) Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 55 788-92 PubMed GONUTS page
↑ ^18.0 ^18.1 Chelikani, PK et al. (2006) Ghrelin attenuates the inhibitory effects of glucagon-like peptide-1 and peptide YY(3-36) on food intake and gastric emptying in rats. Diabetes 55 3038-46 PubMed GONUTS page
↑ ^19.0 ^19.1 Murray, CD et al. (2006) Ghrelin augments afferent response to distension in rat isolated jejunum. Neurogastroenterol. Motil. 18 1112-20 PubMed GONUTS page
↑ Wiedemann, T et al. (2016) Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity. Diabetes 65 406-20 PubMed GONUTS page
↑ Stevanovic, D et al. (2006) Central effects of ghrelin on serum growth hormone and morphology of pituitary somatotropes in rats. Exp. Biol. Med. (Maywood) 231 1610-5 PubMed GONUTS page
↑ Wu, R et al. (2004) Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Am. J. Physiol. Heart Circ. Physiol. 287 H1296-302 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dezaki, K et al. (2006) Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55 3486-93 PubMed GONUTS page

[PMID:10604470-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kojima, M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-60 PubMed GONUTS page

[PMID:19666521-2] Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page

[PMID:17543279-3] Yang, M et al. (2007) Ghrelin inhibits apoptosis signal-regulating kinase 1 activity via upregulating heat-shock protein 70. Biochem. Biophys. Res. Commun. 359 373-8 PubMed GONUTS page

[PMID:11756331-4] 4.0 ^4.1 Date, Y et al. (2002) Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 51 124-9 PubMed GONUTS page

[PMID:17705669-5] Bilgin, HM et al. (2008) Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats. Physiol Res 57 563-8 PubMed GONUTS page

[PMID:22516464-6] 6.0 ^6.1 ^6.2 ^6.3 Berrout, L & Isokawa, M (2012) Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Neurosci. Lett. 516 280-4 PubMed GONUTS page

[PMID:26153524-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Cavalier, M et al. (2015) Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus. Eur. J. Neurosci. 42 2568-76 PubMed GONUTS page

[PMID:17033095-8] 8.0 ^8.1 ^8.2 Warzecha, Z et al. (2006) Influence of ghrelin on gastric and duodenal growth and expression of digestive enzymes in young mature rats. J. Physiol. Pharmacol. 57 425-37 PubMed GONUTS page

[PMID:21642627-9] 9.0 ^9.1 Zaniolo, K et al. (2011) Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest. Ophthalmol. Vis. Sci. 52 5376-86 PubMed GONUTS page

[PMID:23525979-10] 10.0 ^10.1 ^10.2 Gong, Y et al. (2014) Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation. J. Gastroenterol. 49 219-30 PubMed GONUTS page

[PMID:19620309-11] 11.0 ^11.1 Theil, MM et al. (2009) Suppression of experimental autoimmune encephalomyelitis by ghrelin. J. Immunol. 183 2859-66 PubMed GONUTS page

[PMID:21874246-12] 12.0 ^12.1 Yang, CG et al. () Down-regulation of ghrelin receptors in the small intestine delays small intestinal transit in vagotomized rats. Mol Med Rep 4 1061-5 PubMed GONUTS page

[PMID:15890336-13] 13.0 ^13.1 ^13.2 Depoortere, I et al. (2005) Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur. J. Pharmacol. 515 160-8 PubMed GONUTS page

[PMID:14551228-14] 14.0 ^14.1 Thompson, NM et al. (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 234-42 PubMed GONUTS page

[PMID:12960077-15] 15.0 ^15.1 Thompson, NM et al. (2003) Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. Endocrinology 144 4859-67 PubMed GONUTS page

[PMID:16647196-16] Gauna, C et al. (2006) Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol. Cell. Endocrinol. 251 103-11 PubMed GONUTS page

[PMID:15994217-17] Kobelt, P et al. (2006) Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 55 788-92 PubMed GONUTS page

[PMID:17065340-18] 18.0 ^18.1 Chelikani, PK et al. (2006) Ghrelin attenuates the inhibitory effects of glucagon-like peptide-1 and peptide YY(3-36) on food intake and gastric emptying in rats. Diabetes 55 3038-46 PubMed GONUTS page

[PMID:17109695-19] 19.0 ^19.1 Murray, CD et al. (2006) Ghrelin augments afferent response to distension in rat isolated jejunum. Neurogastroenterol. Motil. 18 1112-20 PubMed GONUTS page

[PMID:26512025-20] Wiedemann, T et al. (2016) Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity. Diabetes 65 406-20 PubMed GONUTS page

[PMID:17060681-21] Stevanovic, D et al. (2006) Central effects of ghrelin on serum growth hormone and morphology of pituitary somatotropes in rats. Exp. Biol. Med. (Maywood) 231 1610-5 PubMed GONUTS page

[PMID:15155262-22] Wu, R et al. (2004) Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Am. J. Physiol. Heart Circ. Physiol. 287 H1296-302 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17130496-24] Dezaki, K et al. (2006) Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55 3486-93 PubMed GONUTS page

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