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RAT:GBRA1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Gabra1 (synonyms: Gabra-1) | |
| Protein Name(s) | Gamma-aminobutyric acid receptor subunit alpha-1
GABA(A) receptor subunit alpha-1 | |
| External Links | ||
| UniProt | P62813 | |
| EMBL | L08490 AY574250 BC100061 | |
| PIR | JQ0158 | |
| RefSeq | NP_899155.1 XP_006246185.1 XP_006246186.1 | |
| UniGene | Rn.28463 | |
| ProteinModelPortal | P62813 | |
| SMR | P62813 | |
| BioGrid | 248322 | |
| IntAct | P62813 | |
| MINT | MINT-3371441 | |
| STRING | 10116.ENSRNOP00000004725 | |
| BindingDB | P62813 | |
| ChEMBL | CHEMBL343 | |
| GuidetoPHARMACOLOGY | 404 | |
| PhosphoSite | P62813 | |
| PRIDE | P62813 | |
| Ensembl | ENSRNOT00000004725 | |
| GeneID | 29705 | |
| KEGG | rno:29705 | |
| UCSC | RGD:61855 | |
| CTD | 2554 | |
| RGD | 61855 | |
| eggNOG | NOG238757 | |
| GeneTree | ENSGT00760000119010 | |
| HOGENOM | HOG000231337 | |
| HOVERGEN | HBG051707 | |
| InParanoid | P62813 | |
| KO | K05175 | |
| OMA | APNIARD | |
| OrthoDB | EOG7JX342 | |
| PhylomeDB | P62813 | |
| TreeFam | TF315453 | |
| Reactome | REACT_199021 REACT_199029 REACT_270861 | |
| NextBio | 285923 | |
| PRO | PR:P62813 | |
| Proteomes | UP000002494 | |
| Genevestigator | P62813 | |
| GO | GO:0030054 GO:0034707 GO:1902710 GO:0005887 GO:0045211 GO:0008503 GO:0005254 GO:0008144 GO:0004890 GO:0005237 GO:0071420 GO:0006821 GO:0007214 GO:0034220 GO:0051932 | |
| Gene3D | 2.70.170.10 | |
| InterPro | IPR006028 IPR001390 IPR005431 IPR006202 IPR006201 IPR006029 IPR018000 | |
| PANTHER | PTHR18945 | |
| Pfam | PF02931 PF02932 | |
| PRINTS | PR01079 PR01614 PR00253 PR00252 | |
| SUPFAM | SSF63712 SSF90112 | |
| TIGRFAMs | TIGR00860 | |
| PROSITE | PS00236 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1902710 |
GABA receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071420 |
cellular response to histamine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0016917 |
GABA receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0099060 |
integral component of postsynaptic specialization membrane |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099060 |
integral component of postsynaptic specialization membrane |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099060 |
integral component of postsynaptic specialization membrane |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002037) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0002421) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008144 |
drug binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95614 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060078 |
regulation of postsynaptic membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050877 |
nervous system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87888 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87885 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0008503 |
benzodiazepine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001055383 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861899 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005254 |
chloride channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005237 |
inhibitory extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001055383 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004890 |
GABA-A receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14867 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14867 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14867 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P14867 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060078 |
regulation of postsynaptic membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62812 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001390 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006821 |
chloride transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR005431 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008503 |
benzodiazepine receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006821 |
chloride transport |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005237 |
inhibitory extracellular ligand-gated ion channel activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-RNO-8856390 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006821 |
chloride transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005254 |
chloride channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034707 |
chloride channel complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page
- ↑ Saras, A et al. (2008) Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J. Biol. Chem. 283 10470-5 PubMed GONUTS page
- ↑ 3.0 3.1 Nusser, Z et al. (1996) Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proc. Natl. Acad. Sci. U.S.A. 93 11939-44 PubMed GONUTS page
- ↑ 4.0 4.1 Nusser, Z et al. (1996) The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J. Neurosci. 16 103-14 PubMed GONUTS page
- ↑ 5.0 5.1 Kasugai, Y et al. (2010) Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Eur. J. Neurosci. 32 1868-88 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Wieland, HA et al. (1992) A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267 1426-9 PubMed GONUTS page
- ↑ Feng, HJ & Macdonald, RL (2004) Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. J. Neurophysiol. 92 1577-85 PubMed GONUTS page
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Saha, S et al. (2001) Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Mol. Cell. Neurosci. 17 241-57 PubMed GONUTS page
c
- GO:0071420 ! cellular response to histamine
- GO:0030054 ! cell junction
- GO:0007268 ! chemical synaptic transmission
- GO:0034707 ! chloride channel complex
- GO:0005254 ! chloride channel activity
- GO:0006821 ! chloride transport
- GO:1902476 ! chloride transmembrane transport
- Chordata
- Craniata
- GO:0031410 ! cytoplasmic vesicle
- GO:0030659 ! cytoplasmic vesicle membrane
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