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RAT:FST

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Fst
Protein Name(s) Follistatin

FS Activin-binding protein

External Links
UniProt P21674
EMBL M31591
M31586
M31587
M31588
M31589
M31590
S58913
PIR I57698
RefSeq NP_036693.1
UniGene Rn.162557
PDB 1LR7
1LR8
1LR9
2ARP
PDBsum 1LR7
1LR8
1LR9
2ARP
ProteinModelPortal P21674
SMR P21674
IntAct P21674
MINT MINT-1787002
MEROPS I01.966
Ensembl ENSRNOT00000015680
GeneID 24373
KEGG rno:24373
CTD 10468
RGD 2633
eggNOG NOG267610
GeneTree ENSGT00440000033501
HOGENOM HOG000261649
HOVERGEN HBG051666
InParanoid P21674
KO K04661
OMA EAVCASD
OrthoDB EOG7GBFXR
PhylomeDB P21674
TreeFam TF106409
Reactome REACT_198273
EvolutionaryTrace P21674
NextBio 603119
PRO PR:P21674
Proteomes UP000002494
ExpressionAtlas P21674
Genevestigator P21674
GO GO:0005737
GO:0005576
GO:0005634
GO:0048185
GO:0043395
GO:0030509
GO:0008585
GO:0007276
GO:0031069
GO:0002244
GO:0043616
GO:0032926
GO:0045596
GO:0046882
GO:0000122
GO:0042475
GO:0007389
GO:0051798
GO:0001501
InterPro IPR003645
IPR015369
IPR002350
IPR017878
Pfam PF09289
PF07648
SMART SM00274
SM00280
SUPFAM SSF57581
PROSITE PS51465
PS51364

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0043395

heparan sulfate proteoglycan binding

PMID:12867435[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005575

cellular_component

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051798

positive regulation of hair follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

P

Seeded From UniProt

complete

enables

GO:0048185

activin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

F

Seeded From UniProt

complete

enables

GO:0038102

activin receptor antagonist activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

F

Seeded From UniProt

complete

involved_in

GO:0032926

negative regulation of activin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19883
ensembl:ENSP00000256759

P

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:12203361[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046882

negative regulation of follicle-stimulating hormone secretion

PMID:2725528[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Innis, CA & Hyvönen, M (2003) Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. J. Biol. Chem. 278 39969-77 PubMed GONUTS page
  2. Rossmanith, W et al. (2002) Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control. Mol. Carcinog. 35 1-5 PubMed GONUTS page
  3. Shimasaki, S et al. (1989) Follistatin gene expression in the ovary and extragonadal tissues. Mol. Endocrinol. 3 651-9 PubMed GONUTS page