RAT:F1MAD3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein Pkd1 (ECO:0000313 with Ensembl:ENSRNOP00000015092)
External Links
UniProt	F1MAD3
EMBL	AABR06063007
RefSeq	NP_001244281.1
UniGene	Rn.127770
ProteinModelPortal	F1MAD3
Ensembl	ENSRNOT00000015092
GeneID	24650
KEGG	rno:24650
CTD	5310
RGD	3333
GeneTree	ENSGT00700000104221
InParanoid	F1MAD3
KO	K04985
OMA	GQCNTDL
OrthoDB	EOG76X5Z6
TreeFam	TF316484
NextBio	35583199
Proteomes	UP000002494
GO	GO:0016323 GO:0070062 GO:0005794 GO:0016021 GO:0016328 GO:0016020 GO:0031512 GO:0005634 GO:0002133 GO:0005262 GO:0030246 GO:0048754 GO:0070588 GO:0001502 GO:0007050 GO:0042994 GO:0050982 GO:0048565 GO:0001892 GO:0048806 GO:0007507 GO:0007259 GO:0001889 GO:0060428 GO:0072177 GO:0072218 GO:0072205 GO:0072287 GO:0072237 GO:0021915 GO:0007218 GO:0006807 GO:0018105 GO:0060674 GO:0031659 GO:0007204 GO:0032092 GO:0045944 GO:0006611 GO:0060236 GO:0061136 GO:0034405 GO:0016337 GO:0043588 GO:0021510
Gene3D	2.60.40.670 2.60.60.20 3.10.100.10
InterPro	IPR001304 IPR016186 IPR016187 IPR000483 IPR000203 IPR001611 IPR003591 IPR008976 IPR000372 IPR000434 IPR022409 IPR002859 IPR013122 IPR000601 IPR001024 IPR006228 IPR014010 IPR002889 IPR013994
Pfam	PF01825 PF00059 PF13855 PF00801 PF08016 PF01477 PF02010 PF01822
PRINTS	PR00500
SMART	SM00034 SM00303 SM00308 SM00369 SM00082 SM00013 SM00089 SM00321
SUPFAM	SSF49299 SSF49723 SSF56436
TIGRFAMs	TIGR00864
PROSITE	PS50041 PS50221 PS51450 PS50093 PS50095 PS51111 PS51212

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0016328	lateral plasma membrane	PMID:11336705^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11336705^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:16952559^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11336705^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0042813	P	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0060236	regulation of mitotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0036303	lymph vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0006807	nitrogen compound metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	F	Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C	Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P	Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072287	metanephric distal tubule morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072237	metanephric proximal tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072218	metanephric ascending thin limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F	Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F	Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kleymenova, E et al. (2001) Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol. Cell 7 823-32 PubMed GONUTS page
↑ Masyuk, AI et al. (2006) Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131 911-20 PubMed GONUTS page

[PMID:11336705-1] 1.0 ^1.1 ^1.2 Kleymenova, E et al. (2001) Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol. Cell 7 823-32 PubMed GONUTS page

[PMID:16952559-2] Masyuk, AI et al. (2006) Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131 911-20 PubMed GONUTS page

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RAT:F1MAD3

Contents

Annotations

Notes

References

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