RAT:ELN

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Eln
Protein Name(s)	Elastin Tropoelastin
External Links
UniProt	Q99372
EMBL	BC085910 M60647 M86372 M86355 M86363 M86364 M86366 M86371 M86376 M86373 M86375 J04035
PIR	A36106
RefSeq	NP_036854.1
UniGene	Rn.54384
PhosphoSite	Q99372
PaxDb	Q99372
PRIDE	Q99372
Ensembl	ENSRNOT00000032780
GeneID	25043
KEGG	rno:25043
UCSC	RGD:67394
CTD	2006
RGD	67394
eggNOG	NOG331579
GeneTree	ENSGT00730000111510
InParanoid	Q99372
KO	K14211
OrthoDB	EOG754HSW
TreeFam	TF338594
Reactome	REACT_198592 REACT_198594 REACT_199178
NextBio	605211
PRO	PR:Q99372
Proteomes	UP000002494
ExpressionAtlas	Q99372
Genevestigator	Q99372
GO	GO:0071953 GO:0031012 GO:0005576 GO:0005615 GO:0005739 GO:0005578 GO:0050840 GO:0030023 GO:0007568 GO:0035904 GO:0001974 GO:0071280 GO:0071549 GO:0044344 GO:0071456 GO:0071298 GO:0071407 GO:0071300 GO:0071560 GO:0048251 GO:0030833 GO:0036270 GO:0055093 GO:0007519 GO:0043149
InterPro	IPR003979
PRINTS	PR01500

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005739	mitochondrion	PMID:2971041^[1]	ECO:0000314			C	Figure 5 shows a northern blot analysis of the RNA isolated from Rat. Panel showing the total RNA isolated from aortic tissue	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:9224206^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	PMID:2235137^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:16055482^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:8997264^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:8238530^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071298	cellular response to L-ascorbic acid	PMID:2859894^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	PMID:18847363^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	PMID:9609733^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	PMID:11967999^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18279932^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035904	aorta development	PMID:18803461^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:18847363^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030023	extracellular matrix constituent conferring elasticity	PMID:10090127^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:23354684^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8238530^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:16473861^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	PMID:12844513^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0071953	elastic fiber	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95317 PANTHER:PTN001931357 UniProtKB:P04985 UniProtKB:P15502	C	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003979	F	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003979	C	Seeded From UniProt	complete
involved_in	GO:0048251	elastic fiber assembly	PMID:10090127^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:10090127^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Deak, SB et al. (1988) Rat tropoelastin is synthesized from a 3.5-kilobase mRNA. J. Biol. Chem. 263 13504-7 PubMed GONUTS page
↑ McGowan, SE et al. (1997) Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 17 25-35 PubMed GONUTS page
↑ Noguchi, A et al. (1990) Developmental changes of tropoelastin synthesis by rat pulmonary fibroblasts and effects of dexamethasone. Pediatr. Res. 28 379-82 PubMed GONUTS page
↑ Berk, JL et al. (2005) Hypoxia suppresses elastin repair by rat lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 289 L931-6 PubMed GONUTS page
↑ Berk, JL et al. (1996) Effect of okadaic acid on elastin gene expression in interstitial lung fibroblasts. Am. J. Physiol. 271 L939-48 PubMed GONUTS page
↑ ^6.0 ^6.1 Liu, B et al. (1993) Retinoic acid increases elastin in neonatal rat lung fibroblast cultures. Am. J. Physiol. 265 L430-7 PubMed GONUTS page
↑ Barone, LM et al. (1985) Alteration of the extracellular matrix of smooth muscle cells by ascorbate treatment. Biochim. Biophys. Acta 840 245-54 PubMed GONUTS page
↑ ^8.0 ^8.1 Kothapalli, CR & Ramamurthi, A (2009) Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues. Tissue Eng Part A 15 103-13 PubMed GONUTS page
↑ Bruce, MC & Honaker, CE (1998) Transcriptional regulation of tropoelastin expression in rat lung fibroblasts: changes with age and hyperoxia. Am. J. Physiol. 274 L940-50 PubMed GONUTS page
↑ Carreras, I et al. (2002) Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. J. Cell. Biochem. 85 592-600 PubMed GONUTS page
↑ Gray, MA et al. (2008) Time-dependent alterations of select genes in streptozotocin-induced diabetic rat bladder. Urology 71 1214-9 PubMed GONUTS page
↑ Behmoaras, J et al. (2008) Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Rejuvenation Res 11 883-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Lemack, GE et al. (1999) Altered bladder function in transgenic mice expressing rat elastin. Neurourol. Urodyn. 18 55-68 PubMed GONUTS page
↑ Kostrominova, TY & Brooks, SV (2013) Age-related changes in structure and extracellular matrix protein expression levels in rat tendons. Age (Dordr) 35 2203-14 PubMed GONUTS page
↑ DiCamillo, SJ et al. (2006) Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 291 L232-43 PubMed GONUTS page
↑ Briones, AM et al. (2003) Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. J. Physiol. (Lond.) 552 185-95 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2971041-1] Deak, SB et al. (1988) Rat tropoelastin is synthesized from a 3.5-kilobase mRNA. J. Biol. Chem. 263 13504-7 PubMed GONUTS page

[PMID:9224206-2] McGowan, SE et al. (1997) Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 17 25-35 PubMed GONUTS page

[PMID:2235137-3] Noguchi, A et al. (1990) Developmental changes of tropoelastin synthesis by rat pulmonary fibroblasts and effects of dexamethasone. Pediatr. Res. 28 379-82 PubMed GONUTS page

[PMID:16055482-4] Berk, JL et al. (2005) Hypoxia suppresses elastin repair by rat lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 289 L931-6 PubMed GONUTS page

[PMID:8997264-5] Berk, JL et al. (1996) Effect of okadaic acid on elastin gene expression in interstitial lung fibroblasts. Am. J. Physiol. 271 L939-48 PubMed GONUTS page

[PMID:8238530-6] 6.0 ^6.1 Liu, B et al. (1993) Retinoic acid increases elastin in neonatal rat lung fibroblast cultures. Am. J. Physiol. 265 L430-7 PubMed GONUTS page

[PMID:2859894-7] Barone, LM et al. (1985) Alteration of the extracellular matrix of smooth muscle cells by ascorbate treatment. Biochim. Biophys. Acta 840 245-54 PubMed GONUTS page

[PMID:18847363-8] 8.0 ^8.1 Kothapalli, CR & Ramamurthi, A (2009) Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues. Tissue Eng Part A 15 103-13 PubMed GONUTS page

[PMID:9609733-9] Bruce, MC & Honaker, CE (1998) Transcriptional regulation of tropoelastin expression in rat lung fibroblasts: changes with age and hyperoxia. Am. J. Physiol. 274 L940-50 PubMed GONUTS page

[PMID:11967999-10] Carreras, I et al. (2002) Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. J. Cell. Biochem. 85 592-600 PubMed GONUTS page

[PMID:18279932-11] Gray, MA et al. (2008) Time-dependent alterations of select genes in streptozotocin-induced diabetic rat bladder. Urology 71 1214-9 PubMed GONUTS page

[PMID:18803461-12] Behmoaras, J et al. (2008) Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Rejuvenation Res 11 883-9 PubMed GONUTS page

[PMID:10090127-13] 13.0 ^13.1 ^13.2 Lemack, GE et al. (1999) Altered bladder function in transgenic mice expressing rat elastin. Neurourol. Urodyn. 18 55-68 PubMed GONUTS page

[PMID:23354684-14] Kostrominova, TY & Brooks, SV (2013) Age-related changes in structure and extracellular matrix protein expression levels in rat tendons. Age (Dordr) 35 2203-14 PubMed GONUTS page

[PMID:16473861-15] DiCamillo, SJ et al. (2006) Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 291 L232-43 PubMed GONUTS page

[PMID:12844513-16] Briones, AM et al. (2003) Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. J. Physiol. (Lond.) 552 185-95 PubMed GONUTS page

[PMID:21873635-17] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:ELN

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