RAT:E9PT53

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided.
Protein Name(s)	Wolfram syndrome 1 homolog (Human) (ECO:0000313 with EMBL:EDM00031.1) Wolframin ER transmembrane glycoprotein (ECO:0000313 with Ensembl:ENSRNOP00000032218)
External Links
UniProt	E9PT53
EMBL	AABR07015819 CH473963
UniGene	Rn.229139
STRING	10116.ENSRNOP00000032218
Ensembl	ENSRNOT00000034730
RGD	68954
eggNOG	ENOG410IDYG ENOG4111MAM
GeneTree	ENSGT00390000016928
OMA	GWNHLEP
OrthoDB	EOG091G01MI
TreeFam	TF326849
Reactome	R-RNO-381426 R-RNO-8957275
Proteomes	UP000002494
Bgee	ENSRNOG00000005108
GO	GO:0005783 GO:0030176 GO:0033613 GO:0051117 GO:0048306 GO:0005516 GO:0031625 GO:0055074 GO:0032469 GO:0030968 GO:0042593 GO:0001822 GO:1903892 GO:0043433 GO:1902236 GO:0043524 GO:0043069 GO:0000122 GO:2000675 GO:0050877 GO:0042048 GO:0031016 GO:0045762 GO:0051928 GO:0045927 GO:0051247 GO:0031398 GO:0050821 GO:0003091 GO:0034976 GO:0007605 GO:0030433 GO:0007601
InterPro	IPR026208 IPR026209
PANTHER	PTHR13098
PRINTS	PR02060 PR02061

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050821	protein stabilization	PMID:20160352^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:B2RYC4)	Seeded From UniProt	complete
involved_in	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	PMID:20160352^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G3V909	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20160352^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P06761)\|has_regulation_target:(UniProtKB:Q9R0T3)	Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:20160352^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:G3V909	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:20160352^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B2RYC4	F		Seeded From UniProt	complete
colocalizes_with	GO:0000502	proteasome complex	PMID:20160352^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:20160352^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G3V909	P	has_regulation_target:(UniProtKB:G3V909) part_of:(GO:1903892)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:17110340^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:17110340^[2]	ECO:0001230	mass spectrometry evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:19292454^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:11958857^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:19916172^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:19292454^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	F		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043069	negative regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	F		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	C		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0003091	renal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:0045927	positive regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56695 ensembl:ENSMUSP00000048053	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026208	C		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026208	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Fonseca, SG et al. (2010) Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120 744-55 PubMed GONUTS page
↑ ^2.0 ^2.1 Takamori, S et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127 831-46 PubMed GONUTS page
↑ ^3.0 ^3.1 Yurimoto, S et al. (2009) Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Biochemistry 48 3946-55 PubMed GONUTS page
↑ Kõks, S et al. (2002) Cat odour exposure increases the expression of wolframin gene in the amygdaloid area of rat. Neurosci. Lett. 322 116-20 PubMed GONUTS page
↑ Xu, R et al. (2009) Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. World J. Gastroenterol. 15 5425-31 PubMed GONUTS page

[PMID:20160352-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Fonseca, SG et al. (2010) Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120 744-55 PubMed GONUTS page

[PMID:17110340-2] 2.0 ^2.1 Takamori, S et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127 831-46 PubMed GONUTS page

[PMID:19292454-3] 3.0 ^3.1 Yurimoto, S et al. (2009) Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Biochemistry 48 3946-55 PubMed GONUTS page

[PMID:11958857-4] Kõks, S et al. (2002) Cat odour exposure increases the expression of wolframin gene in the amygdaloid area of rat. Neurosci. Lett. 322 116-20 PubMed GONUTS page

[PMID:19916172-5] Xu, R et al. (2009) Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. World J. Gastroenterol. 15 5425-31 PubMed GONUTS page

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RAT:E9PT53

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