RAT:DGAT1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Dgat1 (synonyms: Dgat)
Protein Name(s)	Diacylglycerol O-acyltransferase 1 Acyl-CoA retinol O-fatty-acyltransferase ARAT Retinol O-fatty-acyltransferase Diglyceride acyltransferase
External Links
UniProt	Q9ERM3
EMBL	AF296131
RefSeq	NP_445889.1
UniGene	Rn.252
MINT	MINT-4569730
BindingDB	Q9ERM3
ChEMBL	CHEMBL6129
PaxDb	Q9ERM3
PRIDE	Q9ERM3
GeneID	84497
KEGG	rno:84497
UCSC	RGD:628673
CTD	8694
RGD	628673
eggNOG	COG5056
HOVERGEN	HBG051341
InParanoid	Q9ERM3
KO	K11155
PhylomeDB	Q9ERM3
UniPathway	UPA00230
NextBio	617075
PRO	PR:Q9ERM3
Proteomes	UP000002494
Genevestigator	Q9ERM3
GO	GO:0005789 GO:0016021 GO:0043231 GO:0019992 GO:0004144 GO:0005504 GO:0050252 GO:0046486 GO:0030073 GO:0019432
InterPro	IPR027251 IPR004299 IPR014371
PANTHER	PTHR10408
Pfam	PF03062
PIRSF	PIRSF000439 PIRSF500231

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000491	positive regulation of hepatic stellate cell activation	PMID:18000880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904729	regulation of intestinal lipid absorption	PMID:18768481^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903998	regulation of eating behavior	PMID:23449193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902224	ketone body metabolic process	PMID:23449193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901738	regulation of vitamin A metabolic process	PMID:18000880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046486	glycerolipid metabolic process	PMID:12193544^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	PMID:23449193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044752	response to human chorionic gonadotropin	PMID:17032584^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:14596837^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	PMID:12193544^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019992	diacylglycerol binding	PMID:14596837^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	PMID:14596837^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	PMID:18768481^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:23449193^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18768481^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:14596837^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004144	diacylglycerol O-acyltransferase activity	PMID:14596837^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004144	diacylglycerol O-acyltransferase activity	PMID:12193544^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333825 PANTHER:PTN000045226 RGD:628673 TAIR:locus:2047665 UniProtKB:I1MSF2 UniProtKB:O75907 UniProtKB:Q5GKZ7 dictyBase:DDB_G0271342	P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000045225 UniProtKB:O75908 UniProtKB:P35610 UniProtKB:Q5GKZ7	C	Seeded From UniProt	complete
enables	GO:0004144	diacylglycerol O-acyltransferase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004797 MGI:MGI:1333825 PANTHER:PTN000045226 RGD:628673 TAIR:locus:2047665 UniProtKB:F1MIW3 UniProtKB:I1MSF2 UniProtKB:O75907 UniProtKB:Q5GKZ7 UniProtKB:Q8MK44	F	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0050252	P	Seeded From UniProt	complete
enables	GO:0004144	diacylglycerol O-acyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027251	F	Seeded From UniProt	complete
enables	GO:0008374	O-acyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014371	F	Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027251	P	Seeded From UniProt	complete
enables	GO:0004144	diacylglycerol O-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.20	F	Seeded From UniProt	complete
enables	GO:0050252	retinol O-fatty-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.76	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
involved_in	GO:0046486	glycerolipid metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00230	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yamaguchi, K et al. (2008) Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology 47 625-35 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cheng, D et al. (2008) Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J. Biol. Chem. 283 29802-11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Schober, G et al. (2013) Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats. J. Lipid Res. 54 1369-84 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kelpe, CL et al. (2002) Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology 143 3326-32 PubMed GONUTS page
↑ Schmidt, J et al. (2006) Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary. Reprod. Fertil. Dev. 18 757-65 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Geelen, MJ (2003) Measurement of diacylglycerol acyltransferase activity in isolated hepatocytes. Anal. Biochem. 322 264-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18000880-1] 1.0 ^1.1 Yamaguchi, K et al. (2008) Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology 47 625-35 PubMed GONUTS page

[PMID:18768481-2] 2.0 ^2.1 ^2.2 Cheng, D et al. (2008) Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J. Biol. Chem. 283 29802-11 PubMed GONUTS page

[PMID:23449193-3] 3.0 ^3.1 ^3.2 ^3.3 Schober, G et al. (2013) Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats. J. Lipid Res. 54 1369-84 PubMed GONUTS page

[PMID:12193544-4] 4.0 ^4.1 ^4.2 Kelpe, CL et al. (2002) Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology 143 3326-32 PubMed GONUTS page

[PMID:17032584-5] Schmidt, J et al. (2006) Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary. Reprod. Fertil. Dev. 18 757-65 PubMed GONUTS page

[PMID:14596837-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Geelen, MJ (2003) Measurement of diacylglycerol acyltransferase activity in isolated hepatocytes. Anal. Biochem. 322 264-8 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:DGAT1

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