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RAT:DEF4

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Np4
Protein Name(s) Neutrophil antibiotic peptide NP-4

RatNP-4 Neutrophil defensin 4

External Links
UniProt Q62714
EMBL U16684
U50355
PIR C60113
RefSeq NP_775421.1
UniGene Rn.234314
ProteinModelPortal Q62714
SMR Q62714
PRIDE Q62714
Ensembl ENSRNOT00000035128
GeneID 286958
KEGG rno:286958
UCSC RGD:727857
CTD 286958
RGD 727857
GeneTree ENSGT00730000111183
HOGENOM HOG000233351
HOVERGEN HBG011703
InParanoid Q62714
KO K05230
OrthoDB EOG75TMFQ
PhylomeDB Q62714
TreeFam TF338414
Reactome REACT_199130
REACT_199179
NextBio 625150
Proteomes UP000002494
ExpressionAtlas Q62714
Genevestigator Q62714
GO GO:0005737
GO:0005615
GO:0006952
GO:0042742
GO:0050832
GO:0031640
InterPro IPR016327
IPR006080
IPR002366
IPR006081
PANTHER PTHR11876
Pfam PF00323
PF00879
PIRSF PIRSF001875
SMART SM00048
PROSITE PS00269

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050832

defense response to fungus

PMID:2543629[1]

ECO:0000314

P

TABLE 2, figure 7

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:2543629[1]

ECO:0000314

P

TABLE 2, figure 5

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

involved_in

GO:0051673

membrane disruption in other organism

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99584
MGI:MGI:99592
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99582
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0019731

antibacterial humoral response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:99584
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99584
PANTHER:PTN002275315
UniProtKB:P59666

C

Seeded From UniProt

complete

involved_in

GO:0002227

innate immune response in mucosa

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006080
InterPro:IPR006081

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016327

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002366
InterPro:IPR006080
InterPro:IPR006081
InterPro:IPR016327

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:7594610[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7594610[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0211

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Eisenhauer, PB et al. (1989) Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun. 57 2021-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Yount, NY et al. (1995) Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. J. Immunol. 155 4476-84 PubMed GONUTS page