RAT:DEF1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided.
Protein Name(s)	Neutrophil antibiotic peptide NP-1 RatNP-1 Neutrophil defensin 1
External Links
UniProt	Q62716
EMBL	U16686
PIR	D61014
UniGene	Rn.91221
ProteinModelPortal	Q62716
SMR	Q62716
eggNOG	NOG69207
HOGENOM	HOG000233351
HOVERGEN	HBG011703
NextBio	625278
Proteomes	UP000002494
Genevestigator	Q62716
GO	GO:0005615 GO:0042742 GO:0050832 GO:0031640
InterPro	IPR016327 IPR006080 IPR002366 IPR006081
PANTHER	PTHR11876
Pfam	PF00323 PF00879
PIRSF	PIRSF001875
SMART	SM00048
PROSITE	PS00269

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050829	defense response to Gram-negative bacterium	PMID:2543629^[1]	ECO:0000314			P	TABLE 2, figure 5	complete
	GO:0050830	defense response to Gram-positive bacterium	PMID:2543629^[1]	ECO:0000314			P	TABLE 2, figure 6	complete
	GO:0050832	defense response to fungus	PMID:2543629^[1]	ECO:0000314			P	TABLE 2, figure 7	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99584 MGI:MGI:99592 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:99584 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99584 PANTHER:PTN002275315 UniProtKB:P59666	C	Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006080 InterPro:IPR006081	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016327	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002366 InterPro:IPR006080 InterPro:IPR006081 InterPro:IPR016327	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0295	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0295	P	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0211	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Eisenhauer, PB et al. (1989) Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun. 57 2021-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2543629-1] 1.0 ^1.1 ^1.2 Eisenhauer, PB et al. (1989) Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun. 57 2021-7 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:DEF1

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