RAT:CSPG4

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cspg4 (synonyms: Ng2)
Protein Name(s)	Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan NG2 HSN tumor-specific antigen
External Links
UniProt	Q00657
EMBL	X56541
PIR	S16025
RefSeq	NP_112284.1
UniGene	Rn.10381
ProteinModelPortal	Q00657
BioGrid	249551
MINT	MINT-143877
STRING	10116.ENSRNOP00000023326
PhosphoSite	Q00657
PaxDb	Q00657
PRIDE	Q00657
GeneID	81651
KEGG	rno:81651
UCSC	RGD:619942
CTD	1464
RGD	619942
eggNOG	NOG261397
HOGENOM	HOG000170195
HOVERGEN	HBG081360
InParanoid	Q00657
KO	K08115
PhylomeDB	Q00657
NextBio	615188
PRO	PR:Q00657
Proteomes	UP000002494
Genevestigator	Q00657
GO	GO:0016324 GO:0005887 GO:0031258 GO:0005886 GO:0005518 GO:0004871 GO:0001525 GO:0006954 GO:0010977 GO:0016322 GO:0010226 GO:0048771
Gene3D	2.60.120.200
InterPro	IPR013320 IPR001791
Pfam	PF00054 PF02210
SMART	SM00282
SUPFAM	SSF49899
PROSITE	PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0005518	collagen binding	PMID:9099729^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20908	F	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:12526031^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:21105148^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	PMID:19439244^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:19878709^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17565360^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:12514214^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048771	tissue remodeling	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0797	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0031258	lamellipodium membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0292	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tillet, E et al. (1997) The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. J. Biol. Chem. 272 10769-76 PubMed GONUTS page
↑ Tang, X et al. (2003) Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J. Neurosci. Res. 71 427-44 PubMed GONUTS page
↑ Donnelly, EM et al. (2010) Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. J Gene Med 12 863-72 PubMed GONUTS page
↑ Orre, K et al. (2009) Chronic lithium treatment decreases NG2 cell proliferation in rat dentate hilus, amygdala and corpus callosum. Prog. Neuropsychopharmacol. Biol. Psychiatry 33 503-10 PubMed GONUTS page
↑ Gao, Q et al. (2010) NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia. Neuroscience 165 386-94 PubMed GONUTS page
↑ Matsumoto, H et al. (2008) Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 28 149-63 PubMed GONUTS page
↑ Ughrin, YM et al. (2003) Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. J. Neurosci. 23 175-86 PubMed GONUTS page

[PMID:9099729-1] Tillet, E et al. (1997) The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. J. Biol. Chem. 272 10769-76 PubMed GONUTS page

[PMID:12526031-2] Tang, X et al. (2003) Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J. Neurosci. Res. 71 427-44 PubMed GONUTS page

[PMID:21105148-3] Donnelly, EM et al. (2010) Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. J Gene Med 12 863-72 PubMed GONUTS page

[PMID:19439244-4] Orre, K et al. (2009) Chronic lithium treatment decreases NG2 cell proliferation in rat dentate hilus, amygdala and corpus callosum. Prog. Neuropsychopharmacol. Biol. Psychiatry 33 503-10 PubMed GONUTS page

[PMID:19878709-5] Gao, Q et al. (2010) NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia. Neuroscience 165 386-94 PubMed GONUTS page

[PMID:17565360-6] Matsumoto, H et al. (2008) Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 28 149-63 PubMed GONUTS page

[PMID:12514214-7] Ughrin, YM et al. (2003) Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. J. Neurosci. 23 175-86 PubMed GONUTS page

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RAT:CSPG4

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