RAT:CP7A1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cyp7a1 (synonyms: Cyp7)
Protein Name(s)	Cholesterol 7-alpha-monooxygenase CYPVII Cholesterol 7-alpha-hydroxylase Cytochrome P450 7A1
External Links
UniProt	P18125
EMBL	J05509 J02926 J05430 J05460 M59189 M59184 M59185 M59186 M59187 M59188 U01962 X17595 Z14108
PIR	A35376
RefSeq	NP_037074.1
UniGene	Rn.10737
ProteinModelPortal	P18125
SMR	P18125
STRING	10116.ENSRNOP00000012819
BindingDB	P18125
ChEMBL	CHEMBL2339
PaxDb	P18125
PRIDE	P18125
Ensembl	ENSRNOT00000012819
GeneID	25428
KEGG	rno:25428
UCSC	RGD:2482
CTD	1581
RGD	2482
eggNOG	COG2124
GeneTree	ENSGT00550000074551
HOGENOM	HOG000231026
HOVERGEN	HBG051100
InParanoid	P18125
KO	K00489
OMA	FHYTTSA
OrthoDB	EOG7J9VP6
PhylomeDB	P18125
TreeFam	TF105090
BioCyc	MetaCyc:MONOMER-14293
Reactome	REACT_196408 REACT_252303 REACT_253630 REACT_270861
SABIO-RK	P18125
UniPathway	UPA00221
NextBio	606611
PRO	PR:P18125
Proteomes	UP000002494
Genevestigator	P18125
GO	GO:0005789 GO:0043231 GO:0008123 GO:0020037 GO:0005506 GO:0006699 GO:0071397 GO:0071333 GO:0006707 GO:0042632 GO:0070857
Gene3D	1.10.630.10
InterPro	IPR001128 IPR017972 IPR024204 IPR002403
Pfam	PF00067
PIRSF	PIRSF000047
PRINTS	PR00465
SUPFAM	SSF48264
PROSITE	PS00086

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045717	negative regulation of fatty acid biosynthetic process	PMID:23536474^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0045542	positive regulation of cholesterol biosynthetic process	PMID:23536474^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22680	P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	PMID:1694852^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:16081591^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	PMID:2335522^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000671174 RGD:2482	C		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001548757 RGD:2482	P		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106091 PANTHER:PTN000671174 RGD:2482	F		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104978 MGI:MGI:1927096 PANTHER:PTN001548757 RGD:2482 UniProtKB:P22680 UniProtKB:Q9NYL5	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22680 ensembl:ENSP00000301645	P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22680 ensembl:ENSP00000301645	P		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22680 ensembl:ENSP00000301645	F		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22680 ensembl:ENSP00000301645	P		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64505 ensembl:ENSMUSP00000029905	F		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64505 ensembl:ENSMUSP00000029905	P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002403	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002403 InterPro:IPR036396	F		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030681	P		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030681	P		Seeded From UniProt	complete
enables	GO:0008123	cholesterol 7-alpha-monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030681	F		Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002403 InterPro:IPR017972 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002403 InterPro:IPR036396	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030681	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002403 InterPro:IPR017972 InterPro:IPR036396	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030681	P		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	PMID:2335522^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA01058	P		Seeded From UniProt	complete
involved_in	GO:0006699	bile acid biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li, T et al. (2013) Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. Hepatology 58 1111-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Li, YC et al. (1990) Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. J. Biol. Chem. 265 12012-9 PubMed GONUTS page
↑ Maeda, Y et al. (2005) Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Ann. Clin. Lab. Sci. 35 323-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Jelinek, DF et al. (1990) Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265 8190-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23536474-1] 1.0 ^1.1 Li, T et al. (2013) Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. Hepatology 58 1111-21 PubMed GONUTS page

[PMID:1694852-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Li, YC et al. (1990) Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. J. Biol. Chem. 265 12012-9 PubMed GONUTS page

[PMID:16081591-3] Maeda, Y et al. (2005) Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Ann. Clin. Lab. Sci. 35 323-8 PubMed GONUTS page

[PMID:2335522-4] 4.0 ^4.1 Jelinek, DF et al. (1990) Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265 8190-7 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:CP7A1

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