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RAT:CALCA
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Calca (synonyms: Calc) | |
| Protein Name(s) | Calcitonin gene-related peptide 1
Alpha-type CGRP Calcitonin gene-related peptide I CGRP-I | |
| External Links | ||
| UniProt | P01256 | |
| EMBL | L29188 L00109 L00110 V01231 M11597 | |
| PIR | A01524 B44173 | |
| RefSeq | NP_001029127.1 NP_001029128.1 | |
| UniGene | Rn.90085 | |
| MINT | MINT-1504942 | |
| BindingDB | P01256 | |
| ChEMBL | CHEMBL5735 | |
| Ensembl | ENSRNOT00000055124 | |
| GeneID | 24241 | |
| KEGG | rno:24241 | |
| CTD | 796 | |
| RGD | 2254 | |
| GeneTree | ENSGT00390000010511 | |
| HOVERGEN | HBG031362 | |
| OrthoDB | EOG7PCJK5 | |
| Reactome | REACT_199225 REACT_246814 REACT_252751 | |
| NextBio | 602721 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | P01256 | |
| Genevestigator | P01256 | |
| GO | GO:0030424 GO:0005576 GO:0005634 GO:0031716 GO:0005184 GO:0007568 GO:1990090 GO:0071356 GO:0006954 GO:0045776 GO:0045986 GO:0008016 GO:0042311 | |
| InterPro | IPR018360 IPR015476 IPR001693 IPR021117 IPR021116 | |
| PANTHER | PTHR10505 | |
| Pfam | PF00214 | |
| PRINTS | PR00817 | |
| SMART | SM00113 | |
| PROSITE | PS00258 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045986 |
negative regulation of smooth muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045776 |
negative regulation of blood pressure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042311 |
vasodilation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008016 |
regulation of heart contraction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051480 |
regulation of cytosolic calcium ion concentration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000053373 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031716 |
calcitonin receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2151253 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2151253 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2151253 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005184 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001693 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001693 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031716 |
calcitonin receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005184 |
neuropeptide hormone activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Lin, YT et al. (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation 8 126 PubMed GONUTS page
- ↑ 2.0 2.1 Supowit, SC et al. (2001) Nerve growth factor enhances calcitonin gene-related peptide expression in the spontaneously hypertensive rat. Hypertension 37 728-32 PubMed GONUTS page
- ↑ 3.0 3.1 Pokabla, MJ et al. (2002) Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia. Peptides 23 507-14 PubMed GONUTS page
- ↑ 4.0 4.1 Kaygisiz, Z et al. (2003) The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts. Acta Physiol Hung 90 133-46 PubMed GONUTS page
- ↑ Li, XQ et al. (2004) CGRP peptide and regenerating sensory axons. J. Neuropathol. Exp. Neurol. 63 1092-103 PubMed GONUTS page
- ↑ Morrison, JF et al. (2009) Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes. Auton Neurosci 146 76-80 PubMed GONUTS page
- ↑ Boer, PA & Gontijo, JA (2006) Nuclear localization of SP, CGRP, and NK1R in a subpopulation of dorsal root ganglia subpopulation cells in rats. Cell. Mol. Neurobiol. 26 191-207 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Qing, X et al. (2001) mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 280 L547-54 PubMed GONUTS page
- ↑ Larson, SD et al. (2004) Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L286-95 PubMed GONUTS page
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