RAT:CALC

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Calca (synonyms: Calc)
Protein Name(s)	Calcitonin
External Links
UniProt	P01257
EMBL	V01230 V01228 V01229 M26137 M31027 L00109 L00110
PIR	A94259
RefSeq	NP_059034.1 XP_008757898.1
UniGene	Rn.90085
ProteinModelPortal	P01257
SMR	P01257
STRING	10116.ENSRNOP00000014948
PaxDb	P01257
PRIDE	P01257
Ensembl	ENSRNOT00000014948
GeneID	24241
KEGG	rno:24241
CTD	796
RGD	2254
eggNOG	NOG40787
GeneTree	ENSGT00390000010511
HOGENOM	HOG000038203
HOVERGEN	HBG031362
InParanoid	P01257
PhylomeDB	P01257
TreeFam	TF333069
Reactome	REACT_199225 REACT_246814 REACT_252751
NextBio	602721
PRO	PR:P01257
Proteomes	UP000002494
ExpressionAtlas	P01257
Genevestigator	P01257
GO	GO:0030424 GO:0005737 GO:0005615 GO:0043025 GO:0005634 GO:0043195 GO:0031716 GO:0005184 GO:0032147 GO:0007189 GO:0007568 GO:1990090 GO:0071356 GO:0050965 GO:0007566 GO:0007631 GO:0006954 GO:0002548 GO:0045776 GO:0045779 GO:0031645 GO:0030279 GO:0045986 GO:0045892 GO:0007218 GO:0045762 GO:0051482 GO:0045778 GO:0008016 GO:0002027 GO:0009408 GO:0048265 GO:0042311 GO:0001984
InterPro	IPR021118 IPR018360 IPR001693 IPR021117 IPR021116
PANTHER	PTHR10505
Pfam	PF00214
PRINTS	PR00270
SMART	SM00113
PROSITE	PS00258

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:21958434^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:21958434^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045986	negative regulation of smooth muscle contraction	PMID:11230364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:11230364^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:11836000^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	PMID:12903912^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15535136^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11836000^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	PMID:12903912^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:19152794^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21958434^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16763782^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053373 UniProtKB:P01258	P	Seeded From UniProt	complete
enables	GO:0031716	calcitonin receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2151253 PANTHER:PTN002574958 UniProtKB:P01258	F	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2151253 PANTHER:PTN000053373 UniProtKB:P01258	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2151253 MGI:MGI:96382 PANTHER:PTN001629918 RGD:2254 UniProtKB:P01258	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11208722^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	F	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
enables	GO:0031716	calcitonin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	F	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	C	Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01258 ensembl:ENSP00000331746	P	Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0048265	response to pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0045986	negative regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	C	Seeded From UniProt	complete
enables	GO:0031716	calcitonin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	F	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	C	Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	F	Seeded From UniProt	complete
involved_in	GO:0001984	artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70160 ensembl:ENSMUSP00000032907	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001693 InterPro:IPR018360 InterPro:IPR021116 InterPro:IPR021117 InterPro:IPR021118	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001693 InterPro:IPR018360 InterPro:IPR021116 InterPro:IPR021117 InterPro:IPR021118	C	Seeded From UniProt	complete
enables	GO:0031716	calcitonin receptor binding	PMID:11159039^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:15064227^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lin, YT et al. (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation 8 126 PubMed GONUTS page
↑ ^2.0 ^2.1 Supowit, SC et al. (2001) Nerve growth factor enhances calcitonin gene-related peptide expression in the spontaneously hypertensive rat. Hypertension 37 728-32 PubMed GONUTS page
↑ ^3.0 ^3.1 Pokabla, MJ et al. (2002) Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia. Peptides 23 507-14 PubMed GONUTS page
↑ ^4.0 ^4.1 Kaygisiz, Z et al. (2003) The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts. Acta Physiol Hung 90 133-46 PubMed GONUTS page
↑ Li, XQ et al. (2004) CGRP peptide and regenerating sensory axons. J. Neuropathol. Exp. Neurol. 63 1092-103 PubMed GONUTS page
↑ Morrison, JF et al. (2009) Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes. Auton Neurosci 146 76-80 PubMed GONUTS page
↑ Boer, PA & Gontijo, JA (2006) Nuclear localization of SP, CGRP, and NK1R in a subpopulation of dorsal root ganglia subpopulation cells in rats. Cell. Mol. Neurobiol. 26 191-207 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Boku, K et al. (2001) Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120 134-43 PubMed GONUTS page
↑ Qing, X et al. (2001) mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 280 L547-54 PubMed GONUTS page
↑ Larson, SD et al. (2004) Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L286-95 PubMed GONUTS page

[PMID:21958434-1] 1.0 ^1.1 ^1.2 Lin, YT et al. (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation 8 126 PubMed GONUTS page

[PMID:11230364-2] 2.0 ^2.1 Supowit, SC et al. (2001) Nerve growth factor enhances calcitonin gene-related peptide expression in the spontaneously hypertensive rat. Hypertension 37 728-32 PubMed GONUTS page

[PMID:11836000-3] 3.0 ^3.1 Pokabla, MJ et al. (2002) Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia. Peptides 23 507-14 PubMed GONUTS page

[PMID:12903912-4] 4.0 ^4.1 Kaygisiz, Z et al. (2003) The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts. Acta Physiol Hung 90 133-46 PubMed GONUTS page

[PMID:15535136-5] Li, XQ et al. (2004) CGRP peptide and regenerating sensory axons. J. Neuropathol. Exp. Neurol. 63 1092-103 PubMed GONUTS page

[PMID:19152794-6] Morrison, JF et al. (2009) Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes. Auton Neurosci 146 76-80 PubMed GONUTS page

[PMID:16763782-7] Boer, PA & Gontijo, JA (2006) Nuclear localization of SP, CGRP, and NK1R in a subpopulation of dorsal root ganglia subpopulation cells in rats. Cell. Mol. Neurobiol. 26 191-207 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11208722-9] Boku, K et al. (2001) Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120 134-43 PubMed GONUTS page

[PMID:11159039-10] Qing, X et al. (2001) mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 280 L547-54 PubMed GONUTS page

[PMID:15064227-11] Larson, SD et al. (2004) Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L286-95 PubMed GONUTS page

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RAT:CALC

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