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RAT:ACOT2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Acot2 (synonyms: Mte1) | |
| Protein Name(s) | Acyl-coenzyme A thioesterase 2, mitochondrial
Acyl-CoA thioesterase 2 ARTISt/p43 Acyl coenzyme A thioester hydrolase MTE-I (ECO:0000303 with PMID:7744868[1]) Very-long-chain acyl-CoA thioesterase (ECO:0000303 with PMID:7744868[1]) | |
| External Links | ||
| UniProt | O55171 | |
| EMBL | Y09333 AB010429 | |
| UniGene | Rn.37524 | |
| ProteinModelPortal | O55171 | |
| SMR | O55171 | |
| STRING | 10116.ENSRNOP00000013515 | |
| ESTHER | ratno-acot2 | |
| iPTMnet | O55171 | |
| PhosphoSitePlus | O55171 | |
| PaxDb | O55171 | |
| PRIDE | O55171 | |
| UCSC | RGD:621055 | |
| RGD | 621055 | |
| eggNOG | ENOG410II3X COG1073 | |
| HOGENOM | HOG000116219 | |
| HOVERGEN | HBG000331 | |
| InParanoid | O55171 | |
| PhylomeDB | O55171 | |
| BRENDA | 3.1.2.2 3.1.2.20 | |
| PRO | PR:O55171 | |
| Proteomes | UP000002494 | |
| GO | GO:0005759 GO:0005739 GO:0047617 GO:0052689 GO:0102991 GO:0016290 GO:0006637 GO:0042493 GO:0070849 GO:0009725 GO:0001666 GO:0031667 GO:0042760 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR016662 IPR014940 IPR006862 | |
| Pfam | PF08840 PF04775 | |
| PIRSF | PIRSF016521 | |
| SUPFAM | SSF53474 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070849 |
response to epidermal growth factor |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047617 |
acyl-CoA hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042760 |
very long-chain fatty acid catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016290 |
palmitoyl-CoA hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009725 |
response to hormone |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006637 |
acyl-CoA metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047617 |
acyl-CoA hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1349396 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006637 |
acyl-CoA metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2159619 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2140197 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006637 |
acyl-CoA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016790 |
thiolester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102991 |
myristoyl-CoA hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016290 |
palmitoyl-CoA hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Svensson, LT et al. (1995) Very long chain and long chain acyl-CoA thioesterases in rat liver mitochondria. Identification, purification, characterization, and induction by peroxisome proliferators. J. Biol. Chem. 270 12177-83 PubMed GONUTS page
- ↑ 2.0 2.1 Stavinoha, MA et al. (2004) Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 287 E888-95 PubMed GONUTS page
- ↑ Castilla, R et al. (2008) New enzymes involved in the mechanism of action of epidermal growth factor in a clonal strain of Leydig tumor cells. Endocrinology 149 3743-52 PubMed GONUTS page
- ↑ Svensson, LT et al. (1998) Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver. Biochem. J. 329 ( Pt 3) 601-8 PubMed GONUTS page
- ↑ 5.0 5.1 King, KL et al. (2007) Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. J. Lipid Res. 48 1511-7 PubMed GONUTS page
- ↑ Moreno, M et al. (2003) Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q. FASEB J. 17 1112-4 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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