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RAT:ACE2
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Ace2 | |
| Protein Name(s) | Angiotensin-converting enzyme 2
ACE-related carboxypeptidase Processed angiotensin-converting enzyme 2 | |
| External Links | ||
| UniProt | Q5EGZ1 | |
| EMBL | AY881244 | |
| RefSeq | NP_001012006.1 | |
| UniGene | Rn.230337 | |
| ProteinModelPortal | Q5EGZ1 | |
| SMR | Q5EGZ1 | |
| BindingDB | Q5EGZ1 | |
| ChEMBL | CHEMBL2311 | |
| MEROPS | M02.006 | |
| PRIDE | Q5EGZ1 | |
| GeneID | 302668 | |
| KEGG | rno:302668 | |
| UCSC | RGD:728890 | |
| CTD | 59272 | |
| RGD | 728890 | |
| HOVERGEN | HBG000265 | |
| InParanoid | Q5EGZ1 | |
| KO | K09708 | |
| PhylomeDB | Q5EGZ1 | |
| Reactome | REACT_198807 | |
| NextBio | 649967 | |
| PRO | PR:Q5EGZ1 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | Q5EGZ1 | |
| Genevestigator | Q5EGZ1 | |
| GO | GO:0009986 GO:0005737 GO:0005615 GO:0070062 GO:0016021 GO:0016020 GO:0005886 GO:0004180 GO:0004175 GO:0046872 GO:0008237 GO:0042277 GO:0017046 GO:0008241 GO:0001618 GO:0003051 GO:0060135 GO:0006508 GO:0032800 GO:0046813 GO:0042312 | |
| InterPro | IPR001548 | |
| PANTHER | PTHR10514 | |
| Pfam | PF01401 | |
| PRINTS | PR00791 | |
| PROSITE | PS00678 PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004180 |
carboxypeptidase activity |
ECO:0000314 |
F |
Table 1 |
complete | |||||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060135 |
maternal process involved in female pregnancy |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008238 |
exopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001630211 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1917258 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012037 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002575178 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003081 |
regulation of systemic arterial blood pressure by renin-angiotensin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002575179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008241 |
peptidyl-dipeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Murça, TM et al. (2012) Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul. Pept. 177 107-15 PubMed GONUTS page
- ↑ 2.0 2.1 Hayashi, N et al. (2010) The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells. Hypertens. Res. 33 1182-5 PubMed GONUTS page
- ↑ Neves, LA et al. (2008) ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R151-61 PubMed GONUTS page
- ↑ Douglas, GC et al. (2004) The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology 145 4703-11 PubMed GONUTS page
- ↑ Burchill, L et al. (2008) Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Exp. Physiol. 93 622-30 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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