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RAT:ACACA
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Acaca (synonyms: Acac) | |
| Protein Name(s) | Acetyl-CoA carboxylase 1
ACC1 ACC-alpha Biotin carboxylase | |
| External Links | ||
| UniProt | P11497 | |
| EMBL | J03808 M26731 EF121986 EF121987 M26195 M26196 M26197 M55315 | |
| PIR | A35578 | |
| RefSeq | NP_071529.1 | |
| UniGene | Rn.163753 Rn.217177 Rn.44372 | |
| ProteinModelPortal | P11497 | |
| SMR | P11497 | |
| BioGrid | 248868 | |
| STRING | 10116.ENSRNOP00000050703 | |
| BindingDB | P11497 | |
| ChEMBL | CHEMBL2397 | |
| PhosphoSite | P11497 | |
| PaxDb | P11497 | |
| PRIDE | P11497 | |
| GeneID | 60581 | |
| KEGG | rno:60581 | |
| CTD | 31 | |
| RGD | 621248 | |
| eggNOG | COG0511 | |
| HOGENOM | HOG000214115 | |
| HOVERGEN | HBG005371 | |
| InParanoid | P11497 | |
| KO | K11262 | |
| PhylomeDB | P11497 | |
| BRENDA | 6.4.1.2 | |
| UniPathway | UPA00655 | |
| NextBio | 612298 | |
| PRO | PR:P11497 | |
| Proteomes | UP000002494 | |
| Genevestigator | P11497 | |
| GO | GO:0005829 GO:0003989 GO:0005524 GO:0009374 GO:0004075 GO:0019900 GO:0046872 GO:0006084 GO:0006633 GO:2001295 GO:0051289 GO:0042493 GO:0014070 | |
| Gene3D | 3.30.1490.20 3.30.470.20 3.40.50.20 3.90.226.10 | |
| InterPro | IPR013537 IPR011761 IPR013815 IPR013816 IPR001882 IPR011764 IPR005482 IPR000089 IPR005481 IPR000022 IPR005479 IPR029045 IPR011763 IPR011762 IPR016185 IPR011054 IPR011053 | |
| Pfam | PF08326 PF02785 PF00364 PF01039 PF00289 PF02786 | |
| SMART | SM00878 | |
| SUPFAM | SSF51230 SSF51246 SSF52096 SSF52440 | |
| PROSITE | PS50975 PS50979 PS00188 PS50968 PS50989 PS50980 PS00866 PS00867 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051289 |
protein homotetramerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009374 |
biotin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR005479 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004075 |
biotin carboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0003989 |
acetyl-CoA carboxylase activity |
ECO:0000314 |
F |
Figure 4 |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001295 |
malonyl-CoA biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00655 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page
- ↑ Liang, Y et al. (2006) The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment. Metab. Clin. Exp. 55 1411-9 PubMed GONUTS page
- ↑ Harwood, HJ Jr et al. (2003) Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J. Biol. Chem. 278 37099-111 PubMed GONUTS page
- ↑ Rathman, SC et al. (2003) Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. J. Nutr. 133 2857-62 PubMed GONUTS page
- ↑ 5.0 5.1 Moura, MA et al. (2001) Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Metab. Clin. Exp. 50 1493-8 PubMed GONUTS page
