RAT:A0A2U1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Fgf2 (ECO:0000313 with EMBL:ABJ90430.1)
Protein Name(s)	Fibroblast growth factor 2 (ECO:0000313 with EMBL:ABJ90430.1)
External Links
UniProt	A0A2U1
EMBL	EF030430
ProteinModelPortal	A0A2U1
STRING	10116.ENSRNOP00000023388
ExpressionAtlas	A0A2U1
Genevestigator	A0A2U1
GO	GO:0005829 GO:0005615 GO:0005634 GO:0000186 GO:0001525 GO:0060128 GO:0008543 GO:0010001 GO:0030324 GO:0060644 GO:0008285 GO:0001759 GO:0045766 GO:0090263 GO:0021940 GO:0010595 GO:0001938 GO:0070374 GO:0045669 GO:0051897 GO:0045944 GO:0051726 GO:0046668 GO:0048678 GO:0048864 GO:0021762 GO:0060129
InterPro	IPR008996 IPR028223 IPR002209
PANTHER	PTHR11486 PTHR11486:SF68
SUPFAM	SSF50353

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000737	negative regulation of stem cell differentiation	PMID:21558414	ECO:0000269			P		FGF2 sustains stem cell character of dormant NS cells in presence of BMP4. Fig 7: Cells cultured with FGF2 and BMP4 retained Nestin and Sox2 expression (Transcription factors vital for ES cell line maintanence). Contrastingly,cells grown in presence of BMP4 and EGF without FGF2 show down-regulation of Sox2 expression and differentiation into GFP-positive astrocytes.	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	P		Seeded From UniProt	complete
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References

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