RAT:5HT1B

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Htr1b (synonyms: 5ht1b)
Protein Name(s)	5-hydroxytryptamine receptor 1B 5-HT-1B 5-HT1B Serotonin receptor 1B
External Links
UniProt	P28564
EMBL	M89954 X62944
PIR	S18637
RefSeq	NP_071561.1
UniGene	Rn.138109
ProteinModelPortal	P28564
SMR	P28564
STRING	10116.ENSRNOP00000017411
BindingDB	P28564
ChEMBL	CHEMBL3459
GuidetoPHARMACOLOGY	2
iPTMnet	P28564
PhosphoSitePlus	P28564
PaxDb	P28564
PRIDE	P28564
Ensembl	ENSRNOT00000017411
GeneID	25075
KEGG	rno:25075
UCSC	RGD:2846
CTD	3351
RGD	2846
eggNOG	KOG3656 ENOG410XRW9
GeneTree	ENSGT00940000154624
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P28564
KO	K04153
OMA	ACWFHMA
OrthoDB	EOG091G06VI
PhylomeDB	P28564
TreeFam	TF316350
Reactome	R-RNO-390666 R-RNO-418594
PRO	PR:P28564
Proteomes	UP000002494
Bgee	ENSRNOG00000013042
Genevisible	P28564
GO	GO:0044305 GO:0005737 GO:0030425 GO:0005887 GO:0099056 GO:0005886 GO:0099154 GO:0008144 GO:0004930 GO:0004993 GO:0030594 GO:0051378 GO:0099626 GO:0007198 GO:0046849 GO:0071312 GO:0035690 GO:0071502 GO:0007268 GO:0042756 GO:0007631 GO:0002031 GO:0007187 GO:0014063 GO:0032229 GO:0051967 GO:1904707 GO:0099171 GO:0007205 GO:0050795 GO:0014059 GO:2000300 GO:0042220 GO:0045471 GO:0051385 GO:0042310
InterPro	IPR002147 IPR002231 IPR000276 IPR017452
PANTHER	PTHR24247:SF16
Pfam	PF00001
PRINTS	PR00513 PR01101 PR00237
SMART	SM01381
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28222	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28222	P		Seeded From UniProt	complete
involved_in	GO:0014063	negative regulation of serotonin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28334	P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28222	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28222	C		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17067296^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0044305)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17067296^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305)	Seeded From UniProt	complete
enables	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	PMID:17067296^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		F	occurs_in:(GO:0044305)	Seeded From UniProt	complete
enables	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	PMID:17067296^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(GO:0044305)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:17067296^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0044305)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:17067296^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:17067296^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:17067296^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051967	negative regulation of synaptic transmission, glutamatergic	PMID:17392733^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	PMID:11882579^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:2947981^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:16212943^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0014053	regulation of gamma-aminobutyric acid secretion	PMID:30217553^[6]	ECO:0000314			P		Figure 6 shows that when 5-HT 1b (CP 93129) is activated the up regulation of GABA secretion due to CB1 activation is blocked. Rat	complete CACAO 13366
involved_in	GO:0042756	drinking behavior	PMID:16839853^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:17509084^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032229	negative regulation of synaptic transmission, GABAergic	PMID:17229091^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:16885935^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:16546225^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:12373419^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:15328035^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15328035^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:15328035^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F		Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099626	P		Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099626	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	P		Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	P		Seeded From UniProt	complete
involved_in	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28222 ensembl:ENSP00000358963	F		Seeded From UniProt	complete
part_of	GO:0099154	serotonergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	C		Seeded From UniProt	complete
involved_in	GO:0071502	cellular response to temperature stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	F		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
involved_in	GO:0014063	negative regulation of serotonin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	F		Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	F		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28334 ensembl:ENSMUSP00000139389	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:X5D7I5 ensembl:ENSP00000358963	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147 InterPro:IPR002231	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147 InterPro:IPR002231	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR002147 InterPro:IPR002231	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147	P		Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002147	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mizutani, H et al. (2006) 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Eur. J. Neurosci. 24 1946-54 PubMed GONUTS page
↑ Lee, JJ et al. (2008) Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. Neuropsychopharmacology 33 340-52 PubMed GONUTS page
↑ Banes, AK & Watts, SW (2002) Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Hypertension 39 394-8 PubMed GONUTS page
↑ Vergé, D et al. (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 3474-82 PubMed GONUTS page
↑ Yan, QS et al. (2005) Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Brain Res. 1060 126-37 PubMed GONUTS page
↑ Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page
↑ Hoplight, BJ et al. (2006) Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Alcohol 38 73-9 PubMed GONUTS page
↑ Barot, SK et al. (2007) 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur. J. Neurosci. 25 3125-31 PubMed GONUTS page
↑ Lemos, JC et al. (2006) Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. Eur. J. Neurosci. 24 3415-30 PubMed GONUTS page
↑ Amato, JL et al. (2007) Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology 32 946-54 PubMed GONUTS page
↑ Scott, C et al. (2006) SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist. Neuropharmacology 50 984-90 PubMed GONUTS page
↑ Lee, MD et al. (2002) 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berl.) 164 49-60 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Yan, QS et al. (2004) Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Brain Res. 1021 82-91 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17067296-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mizutani, H et al. (2006) 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Eur. J. Neurosci. 24 1946-54 PubMed GONUTS page

[PMID:17392733-2] Lee, JJ et al. (2008) Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. Neuropsychopharmacology 33 340-52 PubMed GONUTS page

[PMID:11882579-3] Banes, AK & Watts, SW (2002) Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Hypertension 39 394-8 PubMed GONUTS page

[PMID:2947981-4] Vergé, D et al. (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 3474-82 PubMed GONUTS page

[PMID:16212943-5] Yan, QS et al. (2005) Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Brain Res. 1060 126-37 PubMed GONUTS page

[PMID:30217553-6] Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page

[PMID:16839853-7] Hoplight, BJ et al. (2006) Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Alcohol 38 73-9 PubMed GONUTS page

[PMID:17509084-8] Barot, SK et al. (2007) 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur. J. Neurosci. 25 3125-31 PubMed GONUTS page

[PMID:17229091-9] Lemos, JC et al. (2006) Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. Eur. J. Neurosci. 24 3415-30 PubMed GONUTS page

[PMID:16885935-10] Amato, JL et al. (2007) Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology 32 946-54 PubMed GONUTS page

[PMID:16546225-11] Scott, C et al. (2006) SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist. Neuropharmacology 50 984-90 PubMed GONUTS page

[PMID:12373419-12] Lee, MD et al. (2002) 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berl.) 164 49-60 PubMed GONUTS page

[PMID:15328035-13] 13.0 ^13.1 ^13.2 Yan, QS et al. (2004) Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Brain Res. 1021 82-91 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:5HT1B

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