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RAT:5HT1B

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Htr1b (synonyms: 5ht1b)
Protein Name(s) 5-hydroxytryptamine receptor 1B

5-HT-1B 5-HT1B Serotonin receptor 1B

External Links
UniProt P28564
EMBL M89954
X62944
PIR S18637
RefSeq NP_071561.1
UniGene Rn.138109
ProteinModelPortal P28564
SMR P28564
STRING 10116.ENSRNOP00000017411
BindingDB P28564
ChEMBL CHEMBL3459
GuidetoPHARMACOLOGY 2
iPTMnet P28564
PhosphoSitePlus P28564
PaxDb P28564
PRIDE P28564
Ensembl ENSRNOT00000017411
GeneID 25075
KEGG rno:25075
UCSC RGD:2846
CTD 3351
RGD 2846
eggNOG KOG3656
ENOG410XRW9
GeneTree ENSGT00940000154624
HOGENOM HOG000239242
HOVERGEN HBG106962
InParanoid P28564
KO K04153
OMA ACWFHMA
OrthoDB EOG091G06VI
PhylomeDB P28564
TreeFam TF316350
Reactome R-RNO-390666
R-RNO-418594
PRO PR:P28564
Proteomes UP000002494
Bgee ENSRNOG00000013042
Genevisible P28564
GO GO:0044305
GO:0005737
GO:0030425
GO:0005887
GO:0099056
GO:0005886
GO:0099154
GO:0008144
GO:0004930
GO:0004993
GO:0030594
GO:0051378
GO:0099626
GO:0007198
GO:0046849
GO:0071312
GO:0035690
GO:0071502
GO:0007268
GO:0042756
GO:0007631
GO:0002031
GO:0007187
GO:0014063
GO:0032229
GO:0051967
GO:1904707
GO:0099171
GO:0007205
GO:0050795
GO:0014059
GO:2000300
GO:0042220
GO:0045471
GO:0051385
GO:0042310
InterPro IPR002147
IPR002231
IPR000276
IPR017452
PANTHER PTHR24247:SF16
Pfam PF00001
PRINTS PR00513
PR01101
PR00237
SMART SM01381
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071312

cellular response to alkaloid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28222

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28222

P

Seeded From UniProt

complete

involved_in

GO:0014063

negative regulation of serotonin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28334

P

Seeded From UniProt

complete

involved_in

GO:0007198

adenylate cyclase-inhibiting serotonin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28222

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P28222

C

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:17067296[1]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

occurs_in:(GO:0044305)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:17067296[1]

ECO:0006013

patch-clamp recording evidence used in manual assertion

P

occurs_in:(GO:0044305)

Seeded From UniProt

complete

enables

GO:0099626

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

PMID:17067296[1]

ECO:0006054

pharmacological assay evidence used in manual assertion

F

occurs_in:(GO:0044305)

Seeded From UniProt

complete

enables

GO:0099626

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

PMID:17067296[1]

ECO:0006013

patch-clamp recording evidence used in manual assertion

F

occurs_in:(GO:0044305)

Seeded From UniProt

complete

involved_in

GO:0099171

presynaptic modulation of chemical synaptic transmission

PMID:17067296[1]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

occurs_in:(GO:0044305)

Seeded From UniProt

complete

involved_in

GO:0099171

presynaptic modulation of chemical synaptic transmission

PMID:17067296[1]

ECO:0006013

patch-clamp recording evidence used in manual assertion

P

occurs_in:(GO:0044305)

Seeded From UniProt

complete

part_of

GO:0044305

calyx of Held

PMID:17067296[1]

ECO:0006054

pharmacological assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0044305

calyx of Held

PMID:17067296[1]

ECO:0006013

patch-clamp recording evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051967

negative regulation of synaptic transmission, glutamatergic

PMID:17392733[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051385

response to mineralocorticoid

PMID:11882579[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:2947981[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

PMID:16212943[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0014053

regulation of gamma-aminobutyric acid secretion

PMID:30217553[6]

ECO:0000314

P

Figure 6 shows that when 5-HT 1b (CP 93129) is activated the up regulation of GABA secretion due to CB1 activation is blocked. Rat

complete
CACAO 13366

involved_in

GO:0042756

drinking behavior

PMID:16839853[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

PMID:17509084[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032229

negative regulation of synaptic transmission, GABAergic

PMID:17229091[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014059

regulation of dopamine secretion

PMID:16885935[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:16546225[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:12373419[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:15328035[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15328035[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

PMID:15328035[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030594

neurotransmitter receptor activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:71034

F

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2342
RGD:2343
RGD:2518
RGD:2522
RGD:2851
RGD:61800
RGD:61801
RGD:620023
RGD:62044
RGD:71034

C

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2830
RGD:2846

P

Seeded From UniProt

complete

involved_in

GO:0007187

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2851
RGD:62044

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000037
PANTHER:PTN000664111
RGD:2343
UniProtKB:P08172
UniProtKB:P08908
UniProtKB:P21917
UniProtKB:P28221
UniProtKB:P28222
UniProtKB:P28335
UniProtKB:P28566
UniProtKB:P30546
UniProtKB:P30939
WB:WBGene00001519

C

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004168
FB:FBgn0004573
FB:FBgn0087012
FB:FBgn0263116
MGI:MGI:109323
MGI:MGI:96273
MGI:MGI:96274
MGI:MGI:96276
MGI:MGI:96281
MGI:MGI:96284
PANTHER:PTN000664111
RGD:2845
RGD:2846
RGD:2848
RGD:2850
RGD:2851
RGD:61800
RGD:62044
RGD:62388
RGD:71034
UniProtKB:A0A0B4KFU6
UniProtKB:P08908
UniProtKB:P28221
UniProtKB:P28222
UniProtKB:P28223
UniProtKB:P28335
UniProtKB:P28566
UniProtKB:P30939
UniProtKB:P41595
UniProtKB:P47898
UniProtKB:Q13639
WB:WBGene00004776
WB:WBGene00004779

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2518

F

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0099626

P

Seeded From UniProt

complete

involved_in

GO:0099509

regulation of presynaptic cytosolic calcium ion concentration

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0099626

P

Seeded From UniProt

complete

involved_in

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

P

Seeded From UniProt

complete

involved_in

GO:0071312

cellular response to alkaloid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

P

Seeded From UniProt

complete

involved_in

GO:0007198

adenylate cyclase-inhibiting serotonin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

P

Seeded From UniProt

complete

involved_in

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

C

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28222
ensembl:ENSP00000358963

F

Seeded From UniProt

complete

part_of

GO:0099154

serotonergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

C

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

C

Seeded From UniProt

complete

involved_in

GO:0071502

cellular response to temperature stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

F

Seeded From UniProt

complete

involved_in

GO:0046849

bone remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

involved_in

GO:0014063

negative regulation of serotonin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

F

Seeded From UniProt

complete

involved_in

GO:0007205

protein kinase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

C

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

F

Seeded From UniProt

complete

involved_in

GO:0002031

G protein-coupled receptor internalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28334
ensembl:ENSMUSP00000139389

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:X5D7I5
ensembl:ENSP00000358963

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147
InterPro:IPR002231

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147
InterPro:IPR002231

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR002147
InterPro:IPR002231

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0042310

vasoconstriction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147

P

Seeded From UniProt

complete

involved_in

GO:0046849

bone remodeling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147

P

Seeded From UniProt

complete

involved_in

GO:0050795

regulation of behavior

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002147

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007610

behavior

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0085

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Mizutani, H et al. (2006) 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Eur. J. Neurosci. 24 1946-54 PubMed GONUTS page
  2. Lee, JJ et al. (2008) Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. Neuropsychopharmacology 33 340-52 PubMed GONUTS page
  3. Banes, AK & Watts, SW (2002) Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Hypertension 39 394-8 PubMed GONUTS page
  4. Vergé, D et al. (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 3474-82 PubMed GONUTS page
  5. Yan, QS et al. (2005) Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Brain Res. 1060 126-37 PubMed GONUTS page
  6. Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page
  7. Hoplight, BJ et al. (2006) Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Alcohol 38 73-9 PubMed GONUTS page
  8. Barot, SK et al. (2007) 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur. J. Neurosci. 25 3125-31 PubMed GONUTS page
  9. Lemos, JC et al. (2006) Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. Eur. J. Neurosci. 24 3415-30 PubMed GONUTS page
  10. Amato, JL et al. (2007) Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology 32 946-54 PubMed GONUTS page
  11. Scott, C et al. (2006) SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist. Neuropharmacology 50 984-90 PubMed GONUTS page
  12. Lee, MD et al. (2002) 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berl.) 164 49-60 PubMed GONUTS page
  13. 13.0 13.1 13.2 Yan, QS et al. (2004) Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Brain Res. 1021 82-91 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page