RABIT:G1SR27

Species (Taxon ID)	Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s)	GRB2 (ECO:0000313 with Ensembl:ENSOCUP00000005592)
Protein Name(s)	Uncharacterized protein (ECO:0000313 with Ensembl:ENSOCUP00000005592)
External Links
UniProt	G1SR27
RefSeq	XP_002722985.1
ProteinModelPortal	G1SR27
SMR	G1SR27
IntAct	G1SR27
BindingDB	G1SR27
PRIDE	G1SR27
Ensembl	ENSOCUT00000006468
GeneID	100342500
CTD	2885
GeneTree	ENSGT00550000074482
InParanoid	G1SR27
OMA	RFQDSVQ
OrthoDB	EOG75F4F6
TreeFam	TF354288
Proteomes	UP000001811
GO	GO:0005911 GO:0008180 GO:0005768 GO:0070062 GO:0070436 GO:0012506 GO:0044822 GO:0048646 GO:0060670 GO:0030154 GO:0071479 GO:0008286 GO:0030838 GO:2000379 GO:0009967 GO:0031623 GO:0043408 GO:0042770
Gene3D	3.30.505.10
InterPro	IPR030219 IPR000980 IPR001452
PANTHER	PTHR22820:SF27
Pfam	PF00017 PF00018
PRINTS	PR00401 PR00452
SMART	SM00252 SM00326
SUPFAM	SSF50044 SSF55550
PROSITE	PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0035556	intracellular signal transduction	PMID:12885773^[1]	ECO:0000314			P	Figure 1, 3, 4, 5, 8, & 9 show how Grb2 is part of the signal cascade.	complete CACAO 5910
involved_in	GO:0035556	intracellular signal transduction	PMID:12885773^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005070	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0LPF3 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P	Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P	Seeded From UniProt	complete
part_of	GO:0070436	Grb2-EGFR complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P	Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	P	Seeded From UniProt	complete
part_of	GO:0008180	COP9 signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	C	Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62993 ensembl:ENSP00000376345	F	Seeded From UniProt	complete
involved_in	GO:0060670	branching involved in labyrinthine layer morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	P	Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	P	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	F	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	P	Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	F	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
part_of	GO:0008180	COP9 signalosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	C	Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60631 ensembl:ENSMUSP00000021090	F	Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030219	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page

[PMID:12885773-1] 1.0 ^1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page

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RABIT:G1SR27

Contents

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Notes

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