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RABIT:G1SR27

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Species (Taxon ID) Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s) GRB2 (ECO:0000313 with Ensembl:ENSOCUP00000005592)
Protein Name(s) Uncharacterized protein (ECO:0000313 with Ensembl:ENSOCUP00000005592)
External Links
UniProt G1SR27
RefSeq XP_002722985.1
ProteinModelPortal G1SR27
SMR G1SR27
IntAct G1SR27
BindingDB G1SR27
PRIDE G1SR27
Ensembl ENSOCUT00000006468
GeneID 100342500
CTD 2885
GeneTree ENSGT00550000074482
InParanoid G1SR27
OMA RFQDSVQ
OrthoDB EOG75F4F6
TreeFam TF354288
Proteomes UP000001811
GO GO:0005911
GO:0008180
GO:0005768
GO:0070062
GO:0070436
GO:0012506
GO:0044822
GO:0048646
GO:0060670
GO:0030154
GO:0071479
GO:0008286
GO:0030838
GO:2000379
GO:0009967
GO:0031623
GO:0043408
GO:0042770
Gene3D 3.30.505.10
InterPro IPR030219
IPR000980
IPR001452
PANTHER PTHR22820:SF27
Pfam PF00017
PF00018
PRINTS PR00401
PR00452
SMART SM00252
SM00326
SUPFAM SSF50044
SSF55550
PROSITE PS50001
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0035556

intracellular signal transduction

PMID:12885773[1]

ECO:0000314

P

Figure 1, 3, 4, 5, 8, & 9 show how Grb2 is part of the signal cascade.

complete
CACAO 5910

involved_in

GO:0035556

intracellular signal transduction

PMID:12885773[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009967

positive regulation of signal transduction

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005070

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B0LPF3
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B0LPF3
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B0LPF3
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

P

Seeded From UniProt

complete

involved_in

GO:0071479

cellular response to ionizing radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

P

Seeded From UniProt

complete

part_of

GO:0070436

Grb2-EGFR complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

enables

GO:0043560

insulin receptor substrate binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

involved_in

GO:0042770

signal transduction in response to DNA damage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

P

Seeded From UniProt

complete

involved_in

GO:0031623

receptor internalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

involved_in

GO:0008286

insulin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

P

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

C

Seeded From UniProt

complete

enables

GO:0005168

neurotrophin TRKA receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

enables

GO:0005154

epidermal growth factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

enables

GO:0001784

phosphotyrosine residue binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62993
ensembl:ENSP00000376345

F

Seeded From UniProt

complete

involved_in

GO:0060670

branching involved in labyrinthine layer morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

involved_in

GO:0048646

anatomical structure formation involved in morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

involved_in

GO:0030838

positive regulation of actin filament polymerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

part_of

GO:0012506

vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

C

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60631
ensembl:ENSMUSP00000021090

F

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030219

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Oak, SA et al. (2003) Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278 39287-95 PubMed GONUTS page