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PMID:9829960

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Citation

Yu, XC, Weihe, EK and Margolin, W (1998) Role of the C terminus of FtsK in Escherichia coli chromosome segregation. J. Bacteriol. 180:6424-8

Abstract

FtsK is essential for Escherichia coli cell division. We report that cells lacking the C terminus of FtsK are defective in chromosome segregation as well as septation, often exhibiting asymmetrically positioned nucleoids and large anucleate regions. Combining the corresponding truncated ftsK gene with a mukB null mutation resulted in a synthetic lethal phenotype. When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning.

Links

PubMed PMC107737

Keywords

Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Cell Division/genetics; Cell Division/physiology; Chromosomes, Bacterial/genetics; DNA, Bacterial/genetics; DNA, Bacterial/metabolism; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins; Genes, Bacterial; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/physiology; Mutation; Phenotype; Sequence Deletion

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:FTSK

involved_in

GO:0007059: chromosome segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:FTSK

involved_in

GO:0051301: cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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