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PMID:9800330

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Citation

Li, S, Zadworny, D, Aggrey, SE and Kuhnlein, U (1998) Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens. Anim. Genet. 29:395-7

Abstract

The gene coding for the mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), a pivotal component in gluconeogenesis from lactate via the Cori cycle, was highly polymorphic in strains of egg-type chickens (White Leghorn) of different origins. Based on MspI restriction fragment polymorphisms a total of seven alleles could be distinguished. The allele frequencies were determined in six pairs of strains derived from different genetic base populations. Each pair consisted of two strains which differed in their susceptibility to Marek's disease (MD), a virus-induced neoplastic disease. The frequency of the most common haplotype (M2) was consistently higher in the susceptible strains than in the corresponding resistant strains (P < 0.05, Wilcoxon signed-ranks test), indicating that the observed differences were not due to random genetic drift. This result suggests that PEPCK-M may be a candidate gene which contains genetic variants affecting MD susceptibility. Variations in gluconeogenesis may affect the interplay between proliferation of neoplasia and host metabolism.

Links

PubMed

Keywords

Alleles; Animals; Chickens/genetics; Chickens/metabolism; Gene Frequency; Genetic Variation; Gluconeogenesis/genetics; Marek Disease/enzymology; Marek Disease/genetics; Phosphoenolpyruvate Carboxykinase (GTP)/genetics; Polymorphism, Genetic; Species Specificity

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:PCKGC

involved_in

GO:0006094: gluconeogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGC

enables

GO:0004613: phosphoenolpyruvate carboxykinase (GTP) activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0019661: glucose catabolic process to lactate via pyruvate

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0019516: lactate oxidation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGM

enables

GO:0004613: phosphoenolpyruvate carboxykinase (GTP) activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0018991: oviposition

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0019516: lactate oxidation

ECO:0000304: author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0019661: glucose catabolic process to lactate via pyruvate

ECO:0000304: author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

CHICK:PCKGM

involved_in

GO:0050792: regulation of viral process

ECO:0000316: genetic interaction evidence used in manual assertion

GenBank:AF243438

P

Seeded From UniProt

complete

Notes

See also

References

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