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PMID:9674425

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Citation

Ogryzko, VV, Kotani, T, Zhang, X, Schiltz, RL, Howard, T, Yang, XJ, Howard, BH, Qin, J and Nakatani, Y (1998) Histone-like TAFs within the PCAF histone acetylase complex. Cell 94:35-44

Abstract

PCAF histone acetylase plays a role in regulation of transcription, cell cycle progression, and differentiation. Here, we show that PCAF is found in a complex consisting of more than 20 distinct polypeptides. Strikingly, some polypeptides are identical to TBP-associated factors (TAFs), which are subunits of TFIID. Like TFIID, histone fold-containing factors are present within the PCAF complex. The histone H3- and H2B-like subunits within the PCAF complex are identical to those within TFIID, namely, hTAF(II)31 and hTAF(II)20/15, respectively. The PCAF complex has a novel histone H4-like subunit with similarity to hTAF(II)80 that interacts with the histone H3-like domain of hTAF(II)31. Moreover, the PCAF complex has a novel subunit with WD40 repeats having a similarity to hTAF(II)100.

Links

PubMed

Keywords

Acetyltransferases/chemistry; Amino Acid Sequence; DNA-Binding Proteins/isolation & purification; Fungal Proteins; HeLa Cells; Histone Acetyltransferases; Histones/isolation & purification; Humans; Macromolecular Substances; Mass Spectrometry; Molecular Sequence Data; Nuclear Proteins/isolation & purification; Protein Kinases; Saccharomyces cerevisiae Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Transcription Factors/isolation & purification

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TAD2A

part_of

GO:0000125: PCAF complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAD2A

contributes_to

GO:0004402: histone acetyltransferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TAD2A

involved_in

GO:0043966: histone H3 acetylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TADA3

located_in

GO:0005634: nucleus

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TADA3

involved_in

GO:0006357: regulation of transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TAF5L

involved_in

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TBP

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P21675

F

Seeded From UniProt

complete

HUMAN:TAF1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P20226

F

Seeded From UniProt

complete

HUMAN:TAF10

part_of

GO:0000125: PCAF complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAF10

contributes_to

GO:0004402: histone acetyltransferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TAF10

involved_in

GO:0043966: histone H3 acetylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TAF4

part_of

GO:0000125: PCAF complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAF12

part_of

GO:0000125: PCAF complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAF9

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92831

F

Seeded From UniProt

complete

HUMAN:TAF9

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Y6J9

F

Seeded From UniProt

complete

HUMAN:TAF9

part_of

GO:0000125: PCAF complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAF9

contributes_to

GO:0004402: histone acetyltransferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TAF9

involved_in

GO:0043966: histone H3 acetylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KAT2B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q16594

F

Seeded From UniProt

complete

HUMAN:TAF6L

involved_in

GO:0006357: regulation of transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TAF6L

involved_in

GO:0006338: chromatin remodeling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TAF6L

enables

GO:0003677: DNA binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:TAF6L

part_of

GO:0000118: histone deacetylase complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TAF6L

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q16594

F

Seeded From UniProt

complete


See also

References

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