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PMID:9657962

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Citation

Weir, ML, Klip, A and Trimble, WS (1998) Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. Biochem. J. 333 ( Pt 2):247-51

Abstract

We report the identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein (hVAP-33) that has been implicated in neuronal exocytosis in Aplysia californica. This hVAP-33 shared 50% amino acid identity with the A. californica form and had similar length, structural organization and VAMP-binding abilities. However, in contrast with the neuron-specific expression seen in A. californica, hVAP-33 was broadly expressed, suggesting possible roles in vesicle fusion in both neuronal and non-neuronal cells.

Links

PubMed PMC1219579

Keywords

Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Humans; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; Nerve Tissue Proteins/metabolism; Protein Binding; Protein Conformation; R-SNARE Proteins; RNA/metabolism; SNARE Proteins; Synaptic Transmission; Vesicular Transport Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:VAPA

involved_in

GO:0061025: membrane fusion

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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