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PMID:9641682

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Citation

Patton, BL, Chiu, AY and Sanes, JR (1998) Synaptic laminin prevents glial entry into the synaptic cleft. Nature 393:698-701

Abstract

Presynaptic and postsynaptic membranes directly oppose each other at chemical synapses, minimizing the delay in transmitting information across the synaptic cleft. Extrasynaptic neuronal surfaces, in contrast, are almost entirely covered by processes from glial cells. The exclusion of glial cells from the synaptic cleft, and the long-term stability of synapses, presumably result in large part from the tight adhesion between presynaptic and postsynaptic elements. Here we show that there is another requirement for synaptic maintenance: glial cells of the skeletal neuromuscular synapse, Schwann cells, are actively inhibited from entering the synaptic cleft between the motor nerve terminal and the muscle fibre. One inhibitory component is laminin 11, a heterotrimeric glycoprotein that is concentrated in the synaptic cleft. Regulation of an inhibitory interaction between glial cells and synaptic cleft components may contribute to synaptic rearrangements, and loss of this inhibition may underlie the loss of synapses that results from injury to the postsynaptic cell.

Links

PubMed Online version:10.1038/31502

Keywords

Animals; Cells, Cultured; Chick Embryo; Laminin/physiology; Mice; Neurites/physiology; Schwann Cells/physiology; Schwann Cells/ultrastructure; Synapses/physiology; Synapses/ultrastructure; Synaptic Membranes/physiology; Synaptic Membranes/ultrastructure; Tumor Cells, Cultured

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:LAMB2

acts_upstream_of_or_within

GO:0014044: Schwann cell development

ECO:0000314: direct assay evidence used in manual assertion

P

  • results_in_development_of:(CL:0000692)

Seeded From UniProt

complete


See also

References

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