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Besset, V, Rhee, K and Wolgemuth, DJ (1998) The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system. Mol. Reprod. Dev. 50:18-29


We have isolated a murine cDNA encoding for a novel putative Cdk-related protein kinase, which has been named Pftaire-1, by screening a testis cDNA library for new serine/threonine kinases. Pftaire-1 showed 50% and 49% amino acid identity with Cdk5 and Pctaire-3, respectively, and contains the eleven subdomains characteristic of the protein kinases. By northern blot analysis we detected two transcripts of approximately 5.5 and 4.9 kb in size. These transcripts were expressed at low level in all murine tissues tested, except in the brain, testis and embryo, where high expression was detected. Cellular localization of the mRNAs by in situ hybridization analysis shows that Pftaire-1 is expressed in late pachytene spermatocytes in the testis and in post mitotic neuronal cells both in the brain and the embryo, suggesting a role of Pftaire-1 both in the process of meiosis as well as neuron differentiation and/or function.


PubMed Online version:<18::AID-MRD3>3.0.CO;2-# 10.1002/(SICI)1098-2795(199805)50:1<18::AID-MRD3>3.0.CO;2-#


Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain/enzymology; Cloning, Molecular; Cyclin-Dependent Kinases/genetics; Cyclin-Dependent Kinases/physiology; DNA, Complementary; In Situ Hybridization; Male; Mice; Molecular Sequence Data; Protein Kinases/genetics; Protein Kinases/physiology; Testis/enzymology



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0004674: protein serine/threonine kinase activity

ECO:0000250: sequence similarity evidence used in manual assertion


Seeded From UniProt


See also


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