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PMID:9396743

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Citation

Molina, I, Baars, S, Brill, JA, Hales, KG, Fuller, MT and Ripoll, P (1997) A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. J. Cell Biol. 139:1361-71

Abstract

The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.

Links

PubMed PMC2132616

Keywords

Amino Acid Sequence; Anaphase; Animals; Brain/cytology; Brain/metabolism; Cell Division; Chromatin/physiology; Chromatin/ultrastructure; Chromosomes/physiology; Drosophila/genetics; Drosophila Proteins; Genes, Insect; Insect Proteins/biosynthesis; Insect Proteins/genetics; Introns; Kinesin/biosynthesis; Kinesin/chemistry; Kinesin/genetics; Larva; Mitosis; Molecular Sequence Data; Ploidies; RNA, Messenger/biosynthesis; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:O16866

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O16866

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:O16866

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:O16866

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:O18390

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O18390

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:O18390

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:O18390

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q7JMZ1

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7JMZ1

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:Q7JMZ1

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:Q7JMZ1

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q7KQ58

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KQ58

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:Q7KQ58

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:Q7KQ58

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q960F4

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q960F4

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:Q960F4

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:Q960F4

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VIP4

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VIP4

involved_in

GO:0007018: microtubule-based movement

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

P

Seeded From UniProt

complete

DROME:Q9VIP4

enables

GO:0003777: microtubule motor activity

ECO:0000250: sequence similarity evidence used in manual assertion

FB:FBgn0001308

F

Seeded From UniProt

complete

DROME:Q9VIP4

located_in

GO:0000792: heterochromatin

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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