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PMID:9357983

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Citation

Toyoda, Y, Yoshie, S, Fujita, T, Ito, Y, Nonogaki, T and Miwa, I (1997) Glucokinase is located in secretory granules of pancreatic D-cells. FEBS Lett. 415:281-4

Abstract

We immunohistochemically examined the distribution of glucokinase in rat pancreatic islets. Glucokinase immunoreactivity under light microscopy was detected in the cytoplasm of somatostatin cells as well as in that of insulin cells. No specific immunoreactivity was detected in glucagon and pancreatic polypeptide cells. In somatostatin cells, glucokinase immunoreactivity was located by electron microscopy exclusively within secretory granules.

Links

PubMed

Keywords

Animals; Cytoplasmic Granules/enzymology; Glucagon/analysis; Glucokinase/analysis; Immunohistochemistry; Insulin/analysis; Islets of Langerhans/chemistry; Islets of Langerhans/cytology; Islets of Langerhans/enzymology; Male; Microscopy, Electron; Pancreatic Polypeptide/analysis; Rats; Rats, Wistar; Somatostatin/analysis; Somatostatin-Secreting Cells/enzymology; Somatostatin-Secreting Cells/ultrastructure

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:HXK4

located_in

GO:0030141: secretory granule

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:HXK4

part_of

GO:0030141: secretory granule

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

See also

References

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