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PMID:9298901

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Citation

Lijam, N, Paylor, R, McDonald, MP, Crawley, JN, Deng, CX, Herrup, K, Stevens, KE, Maccaferri, G, McBain, CJ, Sussman, DJ and Wynshaw-Boris, A (1997) Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell 90:895-905

Abstract

Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.

Links

PubMed

Keywords

Adaptor Proteins, Signal Transducing; Animals; Behavior, Animal/physiology; Embryo, Mammalian/physiology; Female; Gene Expression Regulation, Developmental/physiology; Male; Mice; Mice, Knockout/physiology; Motor Neurons/physiology; Nesting Behavior/physiology; Neural Inhibition/physiology; Neurons, Afferent/physiology; Pain Measurement; Phosphoproteins/genetics; Psychomotor Performance/physiology; Sleep; Social Behavior; Vibrissae

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DVL1

acts_upstream_of_or_within

GO:0060134: prepulse inhibition

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137230

P

Seeded From UniProt

complete

MOUSE:DVL1

acts_upstream_of_or_within

GO:0035176: social behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137230

P

Seeded From UniProt

complete


See also

References

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