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PMID:9288753

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Citation

He, Z and Tessier-Lavigne, M (1997) Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90:739-51

Abstract

Extending axons in the developing nervous system are guided to their targets through the coordinate actions of attractive and repulsive guidance cues. The semaphorin family of guidance cues comprises several members that can function as diffusible axonal chemorepellents. To begin to elucidate the mechanisms that mediate the repulsive actions of Collapsin-1/Semaphorin III/D (Sema III), we searched for Sema III-binding proteins in embryonic rat sensory neurons by expression cloning. We report that Sema III binds with high affinity to the transmembrane protein neuropilin, and that antibodies to neuropilin block the ability of Sema III to repel sensory axons and to induce collapse of their growth cones. These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Antigens, Surface/genetics; Antigens, Surface/metabolism; Axons/metabolism; Cloning, Molecular; DNA, Complementary/chemistry; Glycoproteins/metabolism; Humans; In Situ Hybridization; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Molecular Sequence Data; Nerve Growth Factors/metabolism; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neuropilin-1; Rats; Receptors, Cell Surface/metabolism; Semaphorin-3A; Sequence Alignment

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NRP1

involved_in

GO:0007411: axon guidance

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NRP1

involved_in

GO:0007267: cell-cell signaling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NRP1

involved_in

GO:0007165: signal transduction

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NRP1

enables

GO:0005021: vascular endothelial growth factor-activated receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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