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PMID:9252121

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Citation

Chan, VW, Meng, F, Soriano, P, DeFranco, AL and Lowell, CA (1997) Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7:69-81

Abstract

Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling. These mice had a reduced number of peripheral B cells with a greater proportion of immature cells and a higher than normal turnover rate. Aged lyn-/- mice developed splenomegaly, produced autoantibodies, and had an expanded population of B lymphoblasts of the B1 lineage. Splenic B cells from young lyn-/- mice initiated early BCR signaling events, although in a delayed fashion. Unexpectedly, lyn-/- B cells exhibited an enhanced MAP kinase activation and an increased proliferative response to BCR engagement. Stimulation of lyn-/- B cells with intact and F(ab')2 anti-IgM revealed defects in at least two mechanisms that negatively regulate BCR signaling, one of which involves Fc gammaRIIb1.

Links

PubMed

Keywords

Aging/genetics; Aging/immunology; Animals; Antibodies, Anti-Idiotypic/metabolism; Antigens, CD/biosynthesis; Antigens, CD86; Autoantibodies/metabolism; B-Lymphocytes/cytology; B-Lymphocytes/enzymology; B-Lymphocytes/metabolism; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Chickens; Down-Regulation; Lipopolysaccharides/pharmacology; Membrane Glycoproteins/biosynthesis; Mice; Phenotype; Phosphorylation; Pseudogenes; Receptors, IgG/metabolism; Signal Transduction; Surface Properties; Tyrosine/metabolism; src-Family Kinases/deficiency; src-Family Kinases/genetics; src-Family Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:LYN

involved_in

GO:0030889: negative regulation of B cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LYN

involved_in

GO:0002768: immune response-regulating cell surface receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LYN

involved_in

GO:0001782: B cell homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LYN

involved_in

GO:0002513: tolerance induction to self antigen

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LYN

involved_in

GO:0070372: regulation of ERK1 and ERK2 cascade

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LYN

involved_in

GO:0043407: negative regulation of MAP kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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