GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:9202155
| Citation |
Azarian, SM and Travis, GH (1997) The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR). FEBS Lett. 409:247-52 |
|---|---|
| Abstract |
Rim protein (RmP) is a high-Mr membrane glycoprotein that has been localized to the rims of photoreceptor outer segment discs, but its molecular identity is unknown. Here, we describe the purification of RmP and present the sequence of its mRNA. RmP is a new member of the ATP-binding cassette (ABC) transporter superfamily. We show that RmP is expressed specifically in photoreceptors and predominantly in outer segments. Further, RmP is identical to the protein recently shown to be affected in recessive Stargardt's disease. RmP is the first ABC transporter observed in photoreceptors and may play a role in the photoresponse. |
| Links | |
| Keywords |
ATP-Binding Cassette Transporters/chemistry; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/isolation & purification; Amino Acid Sequence; Animals; Cattle; Chromosome Mapping; Chromosomes, Human, Pair 1; DNA, Complementary/isolation & purification; Genes, Recessive; Humans; Macular Degeneration/genetics; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/genetics; Membrane Glycoproteins/isolation & purification; Mice; Molecular Sequence Data; Organ Specificity; Rod Cell Outer Segment/chemistry |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
