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PMID:9162007

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Citation

Tang, H, Gaietta, GM, Fischer, WH, Ellisman, MH and Wong-Staal, F (1997) A cellular cofactor for the constitutive transport element of type D retrovirus. Science 276:1412-5

Abstract

A human nuclear protein that specifically interacts with the constitutive transport element (CTE) of simian retrovirus was identified as adenosine 5'-triphosphate-dependent RNA helicase A. This protein could bind to functional CTE but not to inactive CTE mutants. The interaction of helicase A with CTE was distinct from previously described helicase activity of this protein. Helicase A shuttled from the nucleus to the cytoplasm in the presence of a transcription inhibitor or in cells transiently overexpressing CTE-containing RNA. In vivo colocalization of helicase A and CTE was observed in experiments that combined in situ hybridization and immunostaining. These results suggest that helicase A plays a role in the nuclear export of CTE-containing RNA.

Links

PubMed

Keywords

Adenosine Triphosphate/metabolism; Betaretrovirus/genetics; Betaretrovirus/metabolism; Biological Transport; Cell Nucleus/metabolism; HeLa Cells; Humans; Mutation; Nuclear Proteins/metabolism; Protein Binding; RNA Helicases; RNA Nucleotidyltransferases/metabolism; RNA, Viral/genetics; RNA, Viral/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DHX9

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DHX9

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DHX9

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DHX9

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DHX9

enables

GO:1990825: sequence-specific mRNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

Notes

See also

References

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