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PMID:9007240

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Citation

Heisenberg, CP, Brand, M, Jiang, YJ, Warga, RM, Beuchle, D, van Eeden, FJ, Furutani-Seiki, M, Granato, M, Haffter, P, Hammerschmidt, M, Kane, DA, Kelsh, RN, Mullins, MC, Odenthal, J and Nusslein-Volhard, C (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development 123:191-203

Abstract

We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silberblick (slb), and knollnase (kas). In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded. In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes. Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate. Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.

Links

PubMed

Keywords

Animals; Body Patterning/genetics; Cerebral Ventricles/embryology; Ectoderm/cytology; Ectoderm/physiology; Gastrula/physiology; Genes; Genetic Linkage; Mice; Mutagenesis; Nervous System/embryology; Phenotype; Prosencephalon/embryology; Telencephalon/embryology; Zebrafish/embryology; Zebrafish/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:WNT11

involved_in

GO:0043010: camera-type eye development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1408

P

Seeded From UniProt

complete

DANRE:WNT11

involved_in

GO:0043010: camera-type eye development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-1037

P

Seeded From UniProt

complete

DANRE:AXIN1

involved_in

GO:0001743: lens placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-966

P

Seeded From UniProt

complete

DANRE:AXIN1

involved_in

GO:0030910: olfactory placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-966

P

Seeded From UniProt

complete

DANRE:AXIN1

involved_in

GO:0030900: forebrain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-980202-966

P

Seeded From UniProt

complete


See also

References

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