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PMID:9006055

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Citation

Bergès, H, Oreglia, J, Joseph-Liauzun, E and Fayet, O (1997) Isolation and characterization of a priB mutant of Escherichia coli influencing plasmid copy number of delta rop ColE1-type plasmids. J. Bacteriol. 179:956-8

Abstract

The lethality induced by the overproduction in Escherichia coli of a heterologous protein was used to select bacterial mutants. In one of these, the mutation responsible was mapped to priB. We describe the isolation of this mutant, the sequencing of the mutated gene, and its in vivo effect on plasmid replication.

Links

PubMed PMC178782

Keywords

Alleles; Bacterial Proteins/genetics; Bacteriocin Plasmids/biosynthesis; Chromosome Mapping; DNA Replication; Escherichia coli/genetics; Gene Dosage; Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Humans; Microbial Sensitivity Tests; Mutation; Selection, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:PRIB

involved_in

GO:0006276: plasmid maintenance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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