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PMID:8985181

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Citation

Kadowaki, T, Wilder, E, Klingensmith, J, Zachary, K and Perrimon, N (1996) The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 10:3116-28

Abstract

The Wnt protein Wingless (Wg) functions as a signal in patterning of both the Drosophila embryo and imaginal discs. Lack of porcupine (porc) activity is associated with mutant phenotypes similar to those of wg mutations. In porc mutant embryos, Wg protein is confined to the cells that produce it, suggesting that Porc plays a role in processing or secretion of Wg. porc encodes a novel transmembrane protein that appears to be concentrated at the endoplasmic reticulum. We present both genetic and in vitro evidence demonstrating that porc is involved specifically in the processing of Wg. We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Drosophila Proteins; Drosophila melanogaster/genetics; Endoplasmic Reticulum/metabolism; Extremities/embryology; Female; Gene Expression Regulation, Developmental; Genes, Insect; Hedgehog Proteins; Insect Proteins/physiology; Male; Membrane Proteins/genetics; Membrane Proteins/physiology; Molecular Sequence Data; Polymorphism, Restriction Fragment Length; Protein Processing, Post-Translational; Proteins/physiology; Proto-Oncogene Proteins/physiology; Sequence Alignment; Solubility; Wing/embryology; Wnt1 Protein

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:PORCN

involved_in

GO:0061355: Wnt protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PORCN

involved_in

GO:0030111: regulation of Wnt signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PORCN

located_in

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:PORCN

located_in

GO:0030176: integral component of endoplasmic reticulum membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

DROME:PORCN

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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